Tclin KCNH1 Potassium voltage-gated channel subfamily H member 1

Protein Summary

Description

Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95259
• B1AQ26
• O76035
• Q14CL3

Gene Name

• KCNH1

Ensembl ID

• ENST00000271751
• ENSP00000271751
• ENSG00000143473
• ENST00000638293
• ENSP00000491986
• ENSG00000283965
• ENST00000638907
• ENSP00000492550
• ENST00000638960
• ENSP00000492302
• ENST00000639355
• ENSP00000491578
• ENST00000639420
• ENSP00000492350
• ENST00000639952
• ENSP00000492697
• ENST00000640402
• ENSP00000491804
• ENST00000640528
• ENSP00000491725
• ENST00000640710
• ENSP00000492513

Symbol

• EAG
• EAG1
• EAG
• EAG1
• ZLS1
• TMBTS
• h-eag
• hEAG1
• Kv10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	1
gene perturbation	0.97
trait	0.86
transcription factor binding site profile	0.74

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / H (Eag) Subfamily / Kv10.1/kcnh1 Sub-subfamily / Potassium Voltage-gated Channel Subfamily H Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.25   (req: < 5)

Gene RIFs: 85   (req: <= 3)

Antibodies: 199   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.25   (req: >= 5)

Gene RIFs: 85   (req: > 3)

Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9