Tclin KCNG4 Potassium voltage-gated channel subfamily G member 4

Protein Summary

Description

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 (PubMed:19074135). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TDN1
• Q96H24

Gene Name

• KCNG4

Ensembl ID

• ENST00000308251
• ENSP00000312129
• ENSG00000168418
• ENST00000568181
• ENSP00000457897

Symbol

• KCNG3
• KV6.3
• KV6.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
gene perturbation	0.96
cell line	0.8
molecular function	0.79
cellular component	0.63

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / G Subfamily / Kv6.4/kcng4 Sub-subfamily / Potassium Voltage-gated Channel Subfamily G Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.49   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3