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Tbio
KCNE4
Potassium voltage-gated channel subfamily E member 4

Protein Summary
Description
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. May associate with KCNQ1/KVLTQ1 and inhibit potassium current. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, J ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281830
  • ENSP00000281830
  • ENSG00000152049

Symbol
  • MIRP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
molecular function
0.76
cell line
0.71
microRNA
0.64
tissue sample
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.43   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.43   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
KCNQ1
Tclin
Family:  IC
Novelty:  0.0008956
Score:  0.978
Data Source:  STRINGDB
KCNH2
Tclin
Family:  IC
Novelty:  0.00041611
Score:  0.952
Data Source:  STRINGDB
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
Score:  0.93
Data Source:  STRINGDB
KCNE2
Tbio
Family:  IC
Novelty:  0.0073267
Score:  0.842
Data Source:  STRINGDB
KCNE3
Tbio
Family:  IC
Novelty:  0.01541806
Score:  0.828
Data Source:  STRINGDB
CAMLG
Tbio
Novelty:  0.0088918
Score:  0.808
Data Source:  STRINGDB
KCNE5
Tbio
Novelty:  0.06395873
Score:  0.802
Data Source:  STRINGDB
KCNE1
Tchem
Family:  IC
Novelty:  0.0015463
Score:  0.778
Data Source:  STRINGDB
KCNC4
Tclin
Family:  IC
Novelty:  0.01215128
Score:  0.746
Data Source:  STRINGDB
KCNQ4
Tclin
Family:  IC
Novelty:  0.00626926
Score:  0.742
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 2 - plateau phase
Reactome
Phase 3 - rapid repolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 2 - plateau phase
Phase 3 - rapid repolarisation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
85.2
lymphocyte count
3
2
3
74.7
appendicular lean mass
2
1
2
72.9
leukocyte count
1
1
1
58.4
C-reactive protein measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
85.2
lymphocyte count
3
74.7
appendicular lean mass
2
72.9
leukocyte count
1
58.4
C-reactive protein measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 4
VGNC:8357
735608
Macaque
potassium voltage-gated channel subfamily E regulatory subunit 4
723519
Mouse
MGI:1891125
57814
Rat
RGD:1302957
367302
Dog
potassium voltage-gated channel subfamily E regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:6244]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 4
Macaque
potassium voltage-gated channel subfamily E regulatory subunit 4
Mouse
Rat
Dog
potassium voltage-gated channel subfamily E regulatory subunit 4 [Source:HGNC Symbol;Acc:HGNC:6244]
Publication Statistics
PubMed Score 26.43
PubMed score by year
PubTator Score 14.50
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title