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Tbio
KCNE2
Potassium voltage-gated channel subfamily E member 2

Protein Summary
Description
Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290310
  • ENSP00000290310
  • ENSG00000159197

Symbol
  • LQT5
  • LQT6
  • ATFB4
  • MIRP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.77
gene perturbation
0.77
tissue sample
0.66
cellular component
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.45   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.45   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
KCNH2
Tclin
Family:  IC
Novelty:  0.00041611
Score:  0.995
Data Source:  Reactome,STRINGDB
KCNQ1
Tclin
Family:  IC
Novelty:  0.0008956
Score:  0.993
Data Source:  Reactome,STRINGDB
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
Score:  0.967
Data Source:  Reactome,STRINGDB
KCNE3
Tbio
Family:  IC
Novelty:  0.01541806
Score:  0.884
Data Source:  STRINGDB
SCN5A
Tclin
Family:  IC
Novelty:  0.00050944
Score:  0.867
Data Source:  STRINGDB
KCNE4
Tbio
Family:  IC
Novelty:  0.04524673
Score:  0.842
Data Source:  STRINGDB
KCNJ2
Tchem
Family:  IC
Novelty:  0.00290395
Score:  0.818
Data Source:  STRINGDB
CACNA1C
Tclin
Family:  IC
Novelty:  0.00099998
Score:  0.797
Data Source:  STRINGDB
KCNE5
Tbio
Novelty:  0.06395873
Score:  0.749
Data Source:  STRINGDB
SCN4B
Tbio
Family:  IC
Novelty:  0.02505113
Score:  0.737
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 2 - plateau phase
Reactome
Phase 3 - rapid repolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 2 - plateau phase
Phase 3 - rapid repolarisation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
2
88
90.1
QT interval
5
3
3
3.1
89.5
body height
2
2
2
53.1
hip circumference
1
3
3
43.8
heel bone mineral density
3
1
3
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
88
90.1
QT interval
3
3.1
89.5
body height
2
53.1
hip circumference
3
43.8
heel bone mineral density
3
29.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 2
VGNC:7464
746889
Mouse
MGI:1891123
246133
Rat
RGD:621383
171138
Dog
potassium voltage-gated channel subfamily E regulatory subunit 2
VGNC:42241
403471
Horse
potassium voltage-gated channel subfamily E regulatory subunit 2
VGNC:19271
100062720
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily E regulatory subunit 2
Mouse
Rat
Dog
potassium voltage-gated channel subfamily E regulatory subunit 2
Horse
potassium voltage-gated channel subfamily E regulatory subunit 2
Publication Statistics
PubMed Score 124.45
PubMed score by year
PubTator Score 97.18
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text