Tchem KCNE1 Potassium voltage-gated channel subfamily E member 1

Protein Summary

Description

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15382
• A5H1P2
• Q8N709
• Q91Z94

Gene Name

• KCNE1

Ensembl ID

• ENST00000337385
• ENSP00000337255
• ENSG00000180509
• ENST00000399284
• ENSP00000382225
• ENST00000399286
• ENSP00000382226
• ENST00000399289
• ENSP00000382228
• ENST00000416357
• ENSP00000416258
• ENST00000432085
• ENSP00000412498
• ENST00000611936
• ENSP00000478215
• ENST00000621601
• ENSP00000483895

Symbol

• ISK
• JLNS
• LQT5
• MinK
• JLNS2
• LQT2/5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
biological process	0.87
kinase	0.72
biological term	0.65
chemical	0.58

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Kcne Subfamily / Potassium Voltage-gated Channel Subfamily E Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 707.69   (req: < 5)

Gene RIFs: 159   (req: <= 3)

Antibodies: 243   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 707.69   (req: >= 5)

Gene RIFs: 159   (req: > 3)

Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0