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Tbio
KCNAB2
Voltage-gated potassium channel subunit beta-2

Protein Summary
Description
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000164247
  • ENSP00000164247
  • ENSG00000069424
  • ENST00000341524
  • ENSP00000340824
  • ENST00000352527
  • ENSP00000318772
  • ENST00000378083
  • ENSP00000367323
  • ENST00000378092
  • ENSP00000367332
  • ENST00000378097
  • ENSP00000367337
  • ENST00000458166
  • ENSP00000396167
  • ENST00000602612
  • ENSP00000473602

Symbol
  • KCNA2B
  • KCNK2
  • AKR6A5
  • KCNA2B
  • HKvbeta2
  • KV-BETA-2
  • HKvbeta2.1
  • HKvbeta2.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
disease perturbation
0.87
transcription factor
0.82
gene perturbation
0.74
PubMedID
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.24   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.24   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0