Tbio KCNAB2 Voltage-gated potassium channel subunit beta-2

Protein Summary

Description

Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900). Promotes KCNA4 channel closure (PubMed:7649300, PubMed:11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q13303
• A0AVM9
• A8K1A4
• B0AZR7
• O43659
• Q2YD85
• Q5TG82
• Q5TG83
• Q6ZNE4
• Q99411

Gene Name

• KCNAB2

Ensembl ID

• ENST00000164247
• ENSP00000164247
• ENSG00000069424
• ENST00000341524
• ENSP00000340824
• ENST00000352527
• ENSP00000318772
• ENST00000378083
• ENSP00000367323
• ENST00000378092
• ENSP00000367332
• ENST00000378097
• ENSP00000367337
• ENST00000458166
• ENSP00000396167
• ENST00000602612
• ENSP00000473602

Symbol

• KCNA2B
• KCNK2
• AKR6A5
• KCNA2B
• HKvbeta2
• KV-BETA-2
• HKvbeta2.1
• HKvbeta2.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
disease perturbation	0.87
transcription factor	0.82
gene perturbation	0.74
PubMedID	0.74

Protein Classes

DTO Classes

Protein / Ion Channel / Voltage-gated Potassium Channel -Subunit (Kv) Family / Voltage-gated Potassium Channel Subunit Beta-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.33   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.33   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (201)

Explore Interacting Targets

1 – 10 of 201

• See Interactions on String-DB

KCNAB1

Tbio

Family:  IC

Novelty:  0.01413705

p_int:  0.999999999

p_ni:  1e-9

Score:  0.555

Data Source:  BioPlex,Reactome,STRINGDB

KCNAB3

Tbio

Family:  IC

Novelty:  0.10128237

p_int:  0.999999708

p_ni:  2.92e-7

Score:  0.266

Data Source:  BioPlex,Reactome,STRINGDB

CCAR2

Tbio

Novelty:  0.07397743

p_int:  0.999043987

p_ni:  0.000956013

Score:  0.692

Data Source:  BioPlex,STRINGDB

KCNA5

Tclin

Family:  IC

Novelty:  0.00182891

p_int:  0.998612396

p_ni:  0.001387604

Score:  0.986

Data Source:  BioPlex,STRINGDB

TNNC2

Tbio

Novelty:  0.07759506

p_int:  0.998533181

p_ni:  0.000001571

p_wrong:  0.001465248

Score:  0.284

Data Source:  BioPlex,STRINGDB

MFAP4

Tbio

Novelty:  0.02023782

p_int:  0.99545809

p_ni:  0.00454191

Data Source:  BioPlex

KCNA6

Tclin

Family:  IC

Novelty:  18.19090909

p_int:  0.954293242

p_ni:  0.045706674

p_wrong:  8.3e-8

Score:  0.701

Data Source:  BioPlex,STRINGDB

HAO1

Tclin

Family:  Enzyme

Novelty:  0.00054723

p_int:  0.937255024

p_ni:  0.062744847

p_wrong:  1.28e-7

Score:  0.878

Data Source:  BioPlex,STRINGDB

KCNA10

Tclin

Family:  IC

Novelty:  0.05708808

p_int:  0.860565913

p_ni:  0.139434087

Score:  0.965

Data Source:  BioPlex,STRINGDB

KCNA2

Tclin

Family:  IC

Novelty:  0.00164601

Score:  0.997

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (6)

WikiPathways (5)

Immune System (R-HSA-168256)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695
Reactome	Potassium Channels	99 targets	R-HSA-1296071

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neuronal System	398 targets	R-HSA-112316
Neutrophil degranulation	543 targets	R-HSA-6798695
Potassium Channels	99 targets	R-HSA-1296071

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (3)

Components (13)

Processes (7)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
potassium channel regulator activity	Inferred from Direct Assay (IDA)	UniProtKB
aldo-keto reductase (NADP) activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
voltage-gated potassium channel activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell junction
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Cytoskeleton
Ion channel

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
nervous system phenotype

IDG Resources

Reagents (4)

Data Resources (2)

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Mouse

IDG-KCNAB2-SGFP-MOUSE

Details:

• Allele:  NA
• Construct: NA

Data:

• IDG-KCNAB2-SGFP-MOUSE

Mouse

IDG-KCNAB2-SGRNA-MOUSE

Details:

• Allele:  NA
• Construct: NA

Data:

• IDG-KCNAB2-SGRNA-MOUSE

Antibody

Cell

IDG-HEK293T-KCNAB2-V5-OE

Details:

• RRID:  CVCL_YA59
• Species:  Homo sapiens

Data:

• IDG-HEK293T-KCNAB2-V5-OE

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UCSF

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	potassium voltage-gated channel subfamily A regulatory beta subunit 2		702448
Mouse	potassium voltage-gated channel, shaker-related subfamily, beta member 2	MGI:109239	16498
Rat	potassium voltage-gated channel subfamily A regulatory beta subunit 2	RGD:61828	29738
Dog	potassium voltage-gated channel subfamily A regulatory beta subunit 2	VGNC:42234	489626
Horse	potassium voltage-gated channel subfamily A regulatory beta subunit 2	VGNC:19264	100052362

Species	Name	OMA	EggNOG	Inparanoid
Macaque	potassium voltage-gated channel subfamily A regulatory beta subunit 2
Mouse	potassium voltage-gated channel, shaker-related subfamily, beta member 2
Rat	potassium voltage-gated channel subfamily A regulatory beta subunit 2
Dog	potassium voltage-gated channel subfamily A regulatory beta subunit 2
Horse	potassium voltage-gated channel subfamily A regulatory beta subunit 2

Publication Statistics

PubMed Score 56.33

PubMed score by year

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PubTator Score 24.62

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Related Publications

Text Mined References (21)

GeneRif Annotations (3)

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PMID	Year	Title