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Tbio
KCNAB1
Voltage-gated potassium channel subunit beta-1

Protein Summary
Description
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (PubMed:7499366, PubMed:7603988, PubMed:17156368,PubMed:17540341, PubMed:19713757). Modulates action potentials via its effect on the pore-forming alpha subunits (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the closure of KCNA1, KCNA2 and KCNA5 channels (PubMed:7499366, PubMed:7890032, PubMed:7603988, PubMed:7649300, PubMed:8938711, PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17540341, PubMed:19713757). Accelerates KCNA4 channel closure (PubMed:7890032, PubMed:7649300, PubMed:7890764, PubMed:9763623). Accelerates the closure of heteromeric channels fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302490
  • ENSP00000305858
  • ENSG00000169282
  • ENST00000471742
  • ENSP00000418956
  • ENST00000490337
  • ENSP00000419952

Symbol
  • KCNA1B
  • hKvb3
  • AKR6A3
  • KCNA1B
  • Kvb1.3
  • hKvBeta3
  • KV-BETA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
microRNA
0.73
protein domain
0.73
cell line
0.69
transcription factor
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.86   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 339   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.86   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
p_int:  0.999999999
p_ni:  1e-9
Score:  0.555
Data Source:  BioPlex,Reactome,STRINGDB
KCNA2
Tclin
Family:  IC
Novelty:  0.00164601
Score:  0.994
Data Source:  STRINGDB
KCNA1
Tclin
Family:  IC
Novelty:  0.00183322
Score:  0.992
Data Source:  STRINGDB
KCNA5
Tclin
Family:  IC
Novelty:  0.00182891
Score:  0.987
Data Source:  STRINGDB
KCNA4
Tclin
Family:  IC
Novelty:  0.00362065
Score:  0.985
Data Source:  STRINGDB
KCNA3
Tclin
Family:  IC
Novelty:  0.00169224
Score:  0.979
Data Source:  STRINGDB
KCNB1
Tclin
Family:  IC
Novelty:  0.00187563
Score:  0.972
Data Source:  STRINGDB
KCNV1
Tclin
Family:  IC
Novelty:  0.13544994
Score:  0.969
Data Source:  STRINGDB
KCNS3
Tclin
Family:  IC
Novelty:  0.05882087
Score:  0.966
Data Source:  STRINGDB
KCND3
Tclin
Family:  IC
Novelty:  0.00328276
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental genotype effect measurement
1
1
1
77.1
birth weight
1
1
1
77.1
body mass index
2
2
2
46.5
1
1
0
1.2
40.7
Age-related nuclear cataract
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
parental genotype effect measurement
1
77.1
birth weight
1
77.1
body mass index
2
46.5
0
1.2
40.7
Age-related nuclear cataract
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
706635
Mouse
MGI:109155
16497
Rat
RGD:61827
29737
Dog
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
VGNC:42233
612006
Horse
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
VGNC:19263
100050434
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
Mouse
Rat
Dog
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
Horse
potassium voltage-gated channel subfamily A member regulatory beta subunit 1
Publication Statistics
PubMed Score 68.86
PubMed score by year
PubTator Score 36.73
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title