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Tclin
KCNA5
Potassium voltage-gated channel subfamily A member 5

Protein Summary
Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252321
  • ENSP00000252321
  • ENSG00000130037

Symbol
  • HK2
  • HCK1
  • PCN1
  • ATFB7
  • HPCN1
  • KV1.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
co-expressed gene
0.97
gene perturbation
0.96
biological process
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.01   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.01   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 715
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (205)
KCNA3
Tclin
Family:  IC
Novelty:  0.00169224
p_int:  0.999996051
p_ni:  0.000003931
p_wrong:  1.8e-8
Score:  0.373
Data Source:  BioPlex,STRINGDB
NPHP1
Tbio
Novelty:  0.01113034
p_int:  0.999984928
p_ni:  0.000014997
p_wrong:  7.5e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
C17orf80
Tbio
Novelty:  0.15267004
p_int:  0.999939643
p_ni:  0.00005396
p_wrong:  0.000006397
Data Source:  BioPlex
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
p_int:  0.998612396
p_ni:  0.001387604
Score:  0.986
Data Source:  BioPlex,STRINGDB
CYB5R1
Tbio
Family:  Enzyme
Novelty:  0.07714146
p_int:  0.998374552
p_ni:  0.001625448
Data Source:  BioPlex
ADCK2
Tbio
Family:  Kinase
Novelty:  0.13237052
p_int:  0.99719387
p_ni:  0.002597366
p_wrong:  0.000208764
Score:  0.185
Data Source:  BioPlex,STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.997138296
p_ni:  0.002861704
Data Source:  BioPlex
GOLM1
Tbio
Novelty:  0.00752112
p_int:  0.995478245
p_ni:  0.004521755
Data Source:  BioPlex
DOLK
Tbio
Family:  Enzyme
Novelty:  0.00664639
p_int:  0.991048698
p_ni:  0.000451902
p_wrong:  0.0084994
Data Source:  BioPlex
C1orf43
Tbio
Novelty:  0.13587458
p_int:  0.990314609
p_ni:  0.009685363
p_wrong:  2.8e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
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Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A member 5
VGNC:8439
466930
Macaque
potassium voltage-gated channel subfamily A member 5
711886
Mouse
MGI:96662
16493
Rat
RGD:2953
25470
Dog
potassium voltage-gated channel subfamily A member 5
VGNC:42232
403995
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily A member 5
Macaque
potassium voltage-gated channel subfamily A member 5
Mouse
Rat
Dog
potassium voltage-gated channel subfamily A member 5
Publication Statistics
PubMed Score 561.01
PubMed score by year
PubTator Score 339.30
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title