Tclin KCNA3 Potassium voltage-gated channel subfamily A member 3

Protein Summary

Description

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P22001
• Q5VWN2

Gene Name

• KCNA3

Ensembl ID

• ENST00000369769
• ENSP00000358784
• ENSG00000177272

Symbol

• HGK5
• MK3
• HGK5
• HLK3
• PCN3
• HPCN3
• KV1.3
• HUKIII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.81
cell type or tissue	0.73
gene perturbation	0.67
tissue sample	0.65

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / A (Shaker) Subfamily / Kv1.3/kcna3 Sub-subfamily / Potassium Voltage-gated Channel Subfamily A Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 749.55   (req: < 5)

Gene RIFs: 105   (req: <= 3)

Antibodies: 342   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 749.55   (req: >= 5)

Gene RIFs: 105   (req: > 3)

Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 355

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6