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Tbio
KBTBD8
Kelch repeat and BTB domain-containing protein 8

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000417314
  • ENSP00000401878
  • ENSG00000163376
  • ENST00000460576
  • ENSP00000419738

Symbol
  • KIAA1842
  • TAKRP
  • TAKRP
  • TA-KRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor
0.78
histone modification site profile
0.71
microRNA
0.64
transcription factor binding site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (322)
GAN
Tbio
Novelty:  0.01069743
p_int:  0.999999957
p_ni:  4.2e-8
p_wrong:  1e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.999999871
p_ni:  1.29e-7
Score:  0.911
Data Source:  BioPlex,STRINGDB
KLHL29
Tbio
Novelty:  0.72596897
p_int:  0.99999876
p_ni:  0.000001222
p_wrong:  1.8e-8
Score:  0.825
Data Source:  BioPlex,STRINGDB
ZNF692
Tbio
Family:  TF
Novelty:  0.07012646
p_int:  0.999986478
p_ni:  0.000013456
p_wrong:  6.6e-8
Score:  0.162
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.957
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.926
Data Source:  STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.925
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.925
Data Source:  STRINGDB
HERC3
Tbio
Family:  Enzyme
Novelty:  0.05231675
Score:  0.921
Data Source:  STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch repeat and BTB domain containing 8
VGNC:7979
460491
Mouse
MGI:2661430
243574
Rat
RGD:1563166
500262
Dog
kelch repeat and BTB domain containing 8
VGNC:42226
106557453
Horse
kelch repeat and BTB domain containing 8
VGNC:19258
100064087
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch repeat and BTB domain containing 8
Mouse
Rat
Dog
kelch repeat and BTB domain containing 8
Horse
kelch repeat and BTB domain containing 8
Publication Statistics
PubMed Score 3.45
PubMed score by year
PubTator Score 1.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title