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Tdark
KBTBD7
Kelch repeat and BTB domain-containing protein 7

Protein Summary
Description
The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379483
  • ENSP00000368797
  • ENSG00000120696
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor perturbation
0.8
histone modification site profile
0.74
transcription factor binding site profile
0.73
tissue
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (415)
RBFA
Tbio
Novelty:  0.1061138
p_int:  1
Data Source:  BioPlex
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.999999945
p_ni:  5.5e-8
Data Source:  BioPlex
ERC1
Tbio
Novelty:  0.01251
p_int:  0.999999935
p_ni:  6.3e-8
p_wrong:  2e-9
Data Source:  BioPlex
KBTBD8
Tbio
Novelty:  0.42601278
p_int:  0.999999871
p_ni:  1.29e-7
Score:  0.911
Data Source:  BioPlex,STRINGDB
PARD6B
Tbio
Novelty:  0.08495161
p_int:  0.999999664
p_ni:  3.36e-7
Data Source:  BioPlex
NSUN4
Tbio
Family:  Enzyme
Novelty:  0.15593771
p_int:  0.999997586
p_ni:  0.000002414
Score:  0.157
Data Source:  BioPlex,STRINGDB
KBTBD6
Tdark
Novelty:  1.06955768
p_int:  0.999996107
p_ni:  0.000003893
Score:  0.956
Data Source:  BioPlex,STRINGDB
TNIK
Tchem
Family:  Kinase
Novelty:  0.02681864
p_int:  0.999989064
p_ni:  0.000010814
p_wrong:  1.22e-7
Data Source:  BioPlex
SNX33
Tbio
Novelty:  0.11762505
p_int:  0.999987918
p_ni:  0.000012082
Data Source:  BioPlex
MTERF4
Tbio
Novelty:  0.17764705
p_int:  0.999971578
p_ni:  0.000001567
p_wrong:  0.000026855
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
FLT3 Signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
1
1
21.5
high density lipoprotein cholesterol measurement
1
1
1
13.1
2
1
2
10.8
mosaic loss of chromosome Y measurement
1
1
1
7.8
apolipoprotein A 1 measurement
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
1
21.5
high density lipoprotein cholesterol measurement
1
13.1
2
10.8
mosaic loss of chromosome Y measurement
1
7.8
apolipoprotein A 1 measurement
1
6.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kelch repeat and BTB domain-containing protein 7
698337
Mouse
MGI:2685141
211255
Dog
kelch repeat and BTB domain containing 7
485467
Horse
kelch repeat and BTB domain containing 7
VGNC:49394
100061221
Cow
kelch repeat and BTB domain containing 7
VGNC:53820
539110
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kelch repeat and BTB domain-containing protein 7
Mouse
Dog
kelch repeat and BTB domain containing 7
Horse
kelch repeat and BTB domain containing 7
Cow
kelch repeat and BTB domain containing 7
Publication Statistics
PubMed Score 3.70
PubMed score by year
PubTator Score 1.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title