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Tdark
KBTBD4
Kelch repeat and BTB domain-containing protein 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395288
  • ENSP00000378703
  • ENSG00000123444
  • ENST00000430070
  • ENSP00000415106
  • ENST00000526005
  • ENSP00000433340
  • ENST00000645388
  • ENSP00000495796
  • ENSG00000284900
  • ENST00000646317
  • ENSP00000495324
  • ENST00000647201
  • ENSP00000495892

Symbol
  • BKLHD4
  • BKLHD4
  • HSPC252
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
kinase perturbation
0.88
transcription factor binding site profile
0.77
protein domain
0.73
cell type or tissue
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.32   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
CACUL1
Tbio
Novelty:  0.17361884
p_int:  1
Score:  0.557
Data Source:  BioPlex,STRINGDB
MPG
Tchem
Family:  Enzyme
Novelty:  0.00373538
p_int:  0.999952345
p_ni:  0.000047654
Score:  0.323
Data Source:  BioPlex,STRINGDB
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.999764707
p_ni:  0.000235246
p_wrong:  4.7e-8
Score:  0.159
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.99926391
p_ni:  0.00073609
Score:  0.538
Data Source:  BioPlex,STRINGDB
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
p_int:  0.97581389
p_ni:  0.02409154
p_wrong:  0.00009457
Score:  0.165
Data Source:  BioPlex,STRINGDB
NUDCD3
Tbio
Novelty:  0.32026811
p_int:  0.958736576
p_ni:  0.041263424
Score:  0.318
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.899887559
p_ni:  0.100112441
Data Source:  BioPlex
PI4K2B
Tbio
Family:  Enzyme
Novelty:  0.19272599
p_int:  0.875300199
p_ni:  0.124699796
p_wrong:  5e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
KPNA6
Tbio
Novelty:  0.03516499
p_int:  0.860506233
p_ni:  0.139493767
Score:  0.206
Data Source:  BioPlex,STRINGDB
KPNA5
Tbio
Novelty:  0.0762372
p_int:  0.846678666
p_ni:  0.153321334
Score:  0.258
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
15
4
26
97.2
grip strength measurement
2
2
2
81.8
serum metabolite measurement
2
4
13
78.3
body height
1
1
1
78.1
comparative body size at age 10, self-reported
1
1
1
76.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
26
97.2
grip strength measurement
2
81.8
serum metabolite measurement
13
78.3
body height
1
78.1
comparative body size at age 10, self-reported
1
76.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch repeat and BTB domain containing 4
VGNC:7663
451174
Macaque
kelch repeat and BTB domain containing 4
711452
Mouse
MGI:1914386
67136
Rat
RGD:1310234
311185
Dog
kelch repeat and BTB domain containing 4
VGNC:42225
483621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch repeat and BTB domain containing 4
Macaque
kelch repeat and BTB domain containing 4
Mouse
Rat
Dog
kelch repeat and BTB domain containing 4
Publication Statistics
PubMed Score 2.32
PubMed score by year
PubTator Score 0.63
PubTator score by year
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Related Publications
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PMID
Year
Title