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Tdark
KBTBD2
Kelch repeat and BTB domain-containing protein 2

Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
FMR1
Tbio
Family:  Epigenetic
Novelty:  0.00032203
p_int:  0.999999817
p_ni:  1.81e-7
p_wrong:  2e-9
Score:  0.431
Data Source:  BioPlex,STRINGDB
ALOX15B
Tchem
Family:  Enzyme
Novelty:  0.01578108
p_int:  0.999999544
p_ni:  1.6e-8
p_wrong:  4.4e-7
Score:  0.416
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999994144
p_ni:  0.000005836
p_wrong:  2e-8
Score:  0.655
Data Source:  BioPlex,STRINGDB
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.999367659
p_ni:  0.00000769
p_wrong:  0.000624651
Data Source:  BioPlex
AVL9
Tbio
Novelty:  0.14044287
Score:  0.778
Data Source:  STRINGDB
FKBP9
Tbio
Family:  Enzyme
Novelty:  0.16472204
Score:  0.725
Data Source:  STRINGDB
RP9
Tbio
Novelty:  0.01496992
Score:  0.721
Data Source:  STRINGDB
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
Score:  0.698
Data Source:  STRINGDB
BBS9
Tbio
Novelty:  0.01879869
Score:  0.687
Data Source:  STRINGDB
RNF31
Tbio
Family:  Enzyme
Novelty:  0.01394304
Score:  0.683
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
3
3
91.4
glomerular filtration rate
2
2
2
73.4
mean corpuscular hemoglobin concentration
1
1
1
71.5
waist-hip ratio
1
3
3
57.7
BMI-adjusted waist-hip ratio
1
3
3
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
91.4
glomerular filtration rate
2
73.4
mean corpuscular hemoglobin concentration
1
71.5
waist-hip ratio
3
57.7
BMI-adjusted waist-hip ratio
3
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch repeat and BTB domain containing 2
VGNC:8693
463336
Macaque
kelch repeat and BTB domain containing 2
709126
Mouse
MGI:2384811
210973
Rat
RGD:1310317
312372
Dog
kelch repeat and BTB domain containing 2
VGNC:42223
482391
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch repeat and BTB domain containing 2
Macaque
kelch repeat and BTB domain containing 2
Mouse
Rat
Dog
kelch repeat and BTB domain containing 2
Publication Statistics
PubMed Score 2.76
PubMed score by year
PubTator Score 0.75
PubTator score by year
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Related Publications
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PMID
Year
Title