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Tbio
KATNB1
Katanin p80 WD40 repeat-containing subunit B1

Protein Summary
Description
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa acces ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379661
  • ENSP00000368982
  • ENSG00000140854

Symbol
  • KAT
  • LIS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.89
transcription factor binding site profile
0.78
cellular component
0.76
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.24   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.24   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
KATNA1
Tbio
Family:  Enzyme
Novelty:  0.05656063
p_int:  0.999999962
p_ni:  3.8e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.999999546
p_ni:  4.54e-7
Data Source:  BioPlex
KATNBL1
Tdark
Novelty:  1.43589506
p_int:  0.999999403
p_ni:  5.97e-7
Score:  0.886
Data Source:  BioPlex,STRINGDB
PFDN4
Tbio
Novelty:  0.02133605
p_int:  0.999991821
p_ni:  0.000008179
Score:  0.554
Data Source:  BioPlex,STRINGDB
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.999822067
p_ni:  0.000177863
p_wrong:  7e-8
Data Source:  BioPlex
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.999689612
p_ni:  0.000310388
Data Source:  BioPlex
ASB3
Tbio
Novelty:  0.15921018
p_int:  0.999617158
p_ni:  0.000382824
p_wrong:  1.7e-8
Score:  0.5
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.997129629
p_ni:  0.002870371
Score:  0.529
Data Source:  BioPlex,STRINGDB
BTK
Tclin
Family:  Kinase
Novelty:  0.00050747
p_int:  0.826265473
p_ni:  0.173734506
p_wrong:  2.1e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
KATNAL1
Tbio
Family:  Enzyme
Novelty:  0.11227609
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Genes related to primary cilium development (based on CRISPR)
Name
Explore in Pharos
Explore in Source
Genes related to primary cilium development (based on CRISPR)
Genes related to primary cilium development (based on CRISPR)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
katanin regulatory subunit B1
711862
Mouse
MGI:1921437
74187
Rat
RGD:1311256
291852
Dog
katanin regulatory subunit B1
VGNC:54758
612852
Horse
katanin regulatory subunit B1
VGNC:19250
100052319
Species
Name
OMA
EggNOG
Inparanoid
Macaque
katanin regulatory subunit B1
Mouse
Rat
Dog
katanin regulatory subunit B1
Horse
katanin regulatory subunit B1
Publication Statistics
PubMed Score 11.24
PubMed score by year
PubTator Score 12.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title