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Tchem
KAT8
Histone acetyltransferase KAT8

Protein Summary
Description
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219797
  • ENSP00000219797
  • ENSG00000103510
  • ENST00000448516
  • ENSP00000406037
  • ENST00000543774
  • ENSP00000456933

Symbol
  • MOF
  • MYST1
  • MOF
  • hMOF
  • MYST1
  • ZC2HC8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.79
molecular function
0.79
protein domain
0.73
transcription factor binding site profile
0.73
co-expressed gene
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.4   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.4   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (152)
MSL1
Tbio
Novelty:  3.71231442
p_int:  0.999999972
p_ni:  7e-9
p_wrong:  2.1e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
MSL2
Tbio
Family:  Enzyme
Novelty:  0.01221658
p_int:  0.999999351
p_ni:  6.49e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PHF20
Tbio
Family:  Epigenetic
Novelty:  0.01961423
p_int:  0.999988339
p_ni:  0.00001166
Score:  0.964
Data Source:  BioPlex,STRINGDB
KANSL1
Tbio
Novelty:  0.03032662
Score:  0.993
Data Source:  STRINGDB
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
Score:  0.986
Data Source:  STRINGDB
MSL3
Tbio
Family:  Epigenetic
Novelty:  0.05711824
Score:  0.978
Data Source:  Reactome,STRINGDB
KANSL3
Tbio
Novelty:  0.00150009
Score:  0.978
Data Source:  STRINGDB
WDR5
Tchem
Novelty:  0.0059945
Score:  0.978
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.974
Data Source:  STRINGDB
MCRS1
Tbio
Novelty:  0.03404119
Score:  0.973
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
3
3
82.8
response to anticoagulant
1
1
0
20.4
81
triglyceride measurement
3
3
3
72.3
body mass index
5
2
6
71.6
waist circumference
2
2
2
67.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
3
82.8
response to anticoagulant
0
20.4
81
triglyceride measurement
3
72.3
body mass index
6
71.6
waist circumference
2
67.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 8
VGNC:13723
468102
Mouse
MGI:1915023
67773
Rat
RGD:1311512
310194
Dog
lysine acetyltransferase 8
VGNC:42215
479777
Horse
lysine acetyltransferase 8
VGNC:19247
100064910
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 8
Mouse
Rat
Dog
lysine acetyltransferase 8
Horse
lysine acetyltransferase 8
Publication Statistics
PubMed Score 132.40
PubMed score by year
PubTator Score 528.79
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title