KAT8
Histone acetyltransferase KAT8
Protein Summary
Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
- ENST00000219797
- ENSP00000219797
- ENSG00000103510
- ENST00000448516
- ENSP00000406037
- ENST00000543774
- ENSP00000456933
- MOF
- MYST1
- MOF
- hMOF
- MYST1
- ZC2HC8
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.79 | ||
molecular function | 0.79 | ||
protein domain | 0.73 | ||
transcription factor binding site profile | 0.73 | ||
co-expressed gene | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.4 (req: < 5)
Gene RIFs: 46 (req: <= 3)
Antibodies: 258 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.4 (req: >= 5)
Gene RIFs: 46 (req: > 3)
Antibodies: 258 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (152)
MSL1
Novelty: 3.71231442
p_int: 0.999999972
p_ni: 7e-9
p_wrong: 2.1e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
MSL2
Family: Enzyme
Novelty: 0.01221658
p_int: 0.999999351
p_ni: 6.49e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
PHF20
Family: Epigenetic
Novelty: 0.01961423
p_int: 0.999988339
p_ni: 0.00001166
Score: 0.964
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | HATs acetylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
HATs acetylate histones | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (8)
Components (8)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (27)
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
IGF-1 measurement | 1 | 3 | 3 | 82.8 | |||||
response to anticoagulant | 1 | 1 | 0 | 20.4 | 81 | ||||
triglyceride measurement | 3 | 3 | 3 | 72.3 | |||||
body mass index | 5 | 2 | 6 | 71.6 | |||||
waist circumference | 2 | 2 | 2 | 67.4 | |||||
Items per page:
1 – 5 of 27
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
IGF-1 measurement | 3 | 82.8 | |||||
response to anticoagulant | 0 | 20.4 | 81 | ||||
triglyceride measurement | 3 | 72.3 | |||||
body mass index | 6 | 71.6 | |||||
waist circumference | 2 | 67.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lysine acetyltransferase 8 | VGNC:13723 | 468102 | |||||
Mouse | MGI:1915023 | 67773 | ||||||
Rat | RGD:1311512 | 310194 | ||||||
Dog | lysine acetyltransferase 8 | VGNC:42215 | 479777 | |||||
Horse | lysine acetyltransferase 8 | VGNC:19247 | 100064910 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lysine acetyltransferase 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | lysine acetyltransferase 8 | |||||
Horse | lysine acetyltransferase 8 | |||||
Publication Statistics
PubMed Score 132.40
PubMed score by year
PubTator Score 528.79
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (46)
Items per page:
0 of 0
PMID | Year | Title |
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