Tchem KAT8 Histone acetyltransferase KAT8

Protein Summary

Description

Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q9H7Z6
• A8K4Z1
• G5E9P2
• Q659G0
• Q7LC17
• Q8IY59
• Q8WYB4
• Q8WZ14
• Q9HAC5
• Q9NR35

Gene Name

• KAT8

Ensembl ID

• ENST00000219797
• ENSP00000219797
• ENSG00000103510
• ENST00000448516
• ENSP00000406037
• ENST00000543774
• ENSP00000456933

Symbol

• MOF
• MYST1
• MOF
• hMOF
• MYST1
• ZC2HC8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.79
molecular function	0.79
protein domain	0.73
transcription factor binding site profile	0.73
co-expressed gene	0.72

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Histone Acetyltransferase Kat8

Protein / Transcription Factor / Zinc Finger Transcription Factor / Histone Acetyltransferase Kat8

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Histone Acetyltransferase Kat8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.11   (req: < 5)

Gene RIFs: 46   (req: <= 3)

Antibodies: 258   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.11   (req: >= 5)

Gene RIFs: 46   (req: > 3)

Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0