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Tbio
KAT7
Histone acetyltransferase KAT7

Protein Summary
Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription. The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259021
  • ENSP00000259021
  • ENSG00000136504
  • ENST00000424009
  • ENSP00000398961
  • ENST00000454930
  • ENSP00000413415
  • ENST00000509773
  • ENSP00000424577
  • ENST00000510819
  • ENSP00000423385

Symbol
  • HBO1
  • HBOa
  • MYST2
  • HBO1
  • HBOA
  • MYST2
  • ZC2HC7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
transcription factor binding site profile
0.94
histone modification site profile
0.84
disease perturbation
0.83
cell type or tissue
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.76   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.76   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
JADE1
Tbio
Family:  Epigenetic
Novelty:  0.06758769
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  1
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
JADE2
Tbio
Family:  Epigenetic
Novelty:  0.19820849
p_int:  0.999999998
p_ni:  1e-9
p_wrong:  1e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
JADE3
Tbio
Family:  Epigenetic
Novelty:  0.29964429
p_int:  0.999999992
p_ni:  5e-9
p_wrong:  3e-9
Score:  0.993
Data Source:  BioPlex,STRINGDB
BRPF3
Tchem
Family:  Epigenetic
Novelty:  0.14559787
p_int:  0.999999956
p_ni:  3.3e-8
p_wrong:  1.2e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
BRD1
Tchem
Family:  Epigenetic
Novelty:  0.00412359
p_int:  0.99999629
p_ni:  8.8e-8
p_wrong:  0.000003622
Score:  0.995
Data Source:  BioPlex,STRINGDB
ING5
Tbio
Family:  Epigenetic
Novelty:  0.03585867
p_int:  0.999993828
p_ni:  0.0000058
p_wrong:  3.71e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ING4
Tbio
Family:  Epigenetic
Novelty:  0.01372992
Score:  0.991
Data Source:  Reactome,STRINGDB
BRPF1
Tchem
Family:  Epigenetic
Novelty:  0.02524021
Score:  0.907
Data Source:  STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.897
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
4
4
97.8
mean corpuscular volume
3
3
4
96.9
mosaic loss of chromosome Y measurement
3
2
3
86.9
mean corpuscular hemoglobin concentration
1
1
1
85.6
alkaline phosphatase measurement
3
2
2
10.3
78.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
4
97.8
mean corpuscular volume
4
96.9
mosaic loss of chromosome Y measurement
3
86.9
mean corpuscular hemoglobin concentration
1
85.6
alkaline phosphatase measurement
2
10.3
78.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 7
VGNC:9341
455108
Mouse
MGI:2182799
217127
Dog
lysine acetyltransferase 7
VGNC:42214
491072
Horse
lysine acetyltransferase 7
VGNC:19246
100056161
Cow
lysine acetyltransferase 7
VGNC:30403
508246
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 7
Mouse
Dog
lysine acetyltransferase 7
Horse
lysine acetyltransferase 7
Cow
lysine acetyltransferase 7
Publication Statistics
PubMed Score 66.76
PubMed score by year
PubTator Score 43.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title