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Tchem
KAT6B
Histone acetyltransferase KAT6B

Protein Summary
Description
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287239
  • ENSP00000287239
  • ENSG00000156650
  • ENST00000372711
  • ENSP00000361796
  • ENST00000372714
  • ENSP00000361799
  • ENST00000372724
  • ENSP00000361809
  • ENST00000372725
  • ENSP00000361810
  • ENST00000628038
  • ENSP00000485896
  • ENSG00000281813
  • ENST00000628523
  • ENSP00000487238
  • ENST00000629233
  • ENSP00000487219
  • ENST00000629879
  • ENSP00000486731
  • ENST00000630001
  • ENSP00000486595
  • ENST00000647630
  • ENSP00000497352
  • ENST00000648605
  • ENSP00000497718
  • ENST00000648725
  • ENSP00000497841
  • ENST00000648892
  • ENSP00000497048
  • ENST00000649006
  • ENSP00000498139
  • ENST00000649463
  • ENSP00000497166
  • ENST00000649574
  • ENSP00000497416
  • ENST00000650575
  • ENSP00000497453

Symbol
  • KIAA0383
  • MORF
  • MOZ2
  • MYST4
  • qkf
  • MORF
  • MOZ2
  • GTPTS
  • MYST4
  • ZC2HC6B
  • querkopf
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.95
transcription factor perturbation
0.84
cell type or tissue
0.83
biological process
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.28   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 362.28   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0