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Tchem
KAT6A
Histone acetyltransferase KAT6A

Protein Summary
Description
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265713
  • ENSP00000265713
  • ENSG00000083168
  • ENST00000396930
  • ENSP00000380136

Symbol
  • MOZ
  • MYST3
  • RUNXBP2
  • ZNF220
  • MOZ
  • MRD32
  • MYST3
  • MYST-3
  • ZNF220
  • RUNXBP2
  • ZC2HC6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.95
biological process
0.92
molecular function
0.9
microRNA
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.5   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.5   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 182
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (182)
CHEMBL4468833
Rendered image for CHEMBL4468833
CHEMBL4437798
Rendered image for CHEMBL4437798
CHEMBL4456585
Rendered image for CHEMBL4456585
CHEMBL4475883
Rendered image for CHEMBL4475883
CHEMBL4539384
Rendered image for CHEMBL4539384
CHEMBL4441439
Rendered image for CHEMBL4441439
CHEMBL4521125
Rendered image for CHEMBL4521125
Protein-Protein Interactions (174)
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999993516
p_ni:  0.000006461
p_wrong:  2.2e-8
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.999977568
p_ni:  0.00002162
p_wrong:  8.12e-7
Data Source:  BioPlex
BRPF1
Tchem
Family:  Epigenetic
Novelty:  0.02524021
Score:  0.995
Data Source:  Reactome,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.994
Data Source:  STRINGDB
ING5
Tbio
Family:  Epigenetic
Novelty:  0.03585867
Score:  0.99
Data Source:  Reactome,STRINGDB
BRD1
Tchem
Family:  Epigenetic
Novelty:  0.00412359
Score:  0.989
Data Source:  STRINGDB
BRPF3
Tchem
Family:  Epigenetic
Novelty:  0.14559787
Score:  0.988
Data Source:  STRINGDB
NCOA2
Tbio
Novelty:  0.00510052
Score:  0.986
Data Source:  Reactome,STRINGDB
H3F3C
Tbio
Novelty:  0.07135811
Score:  0.973
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.973
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (108)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
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Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
1
1
79.7
serum non-albumin protein measurement
1
1
1
35
hair color
1
1
0
1.1
7.1
sleep duration
1
1
1
3.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
79.7
serum non-albumin protein measurement
1
35
hair color
0
1.1
7.1
sleep duration
1
3.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 6A
VGNC:7600
464147
Macaque
lysine acetyltransferase 6A
703800
Mouse
MGI:2442415
244349
Rat
RGD:1304892
306571
Dog
lysine acetyltransferase 6A
VGNC:42212
100683464
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine acetyltransferase 6A
Macaque
lysine acetyltransferase 6A
Mouse
Rat
Dog
lysine acetyltransferase 6A
Publication Statistics
PubMed Score 219.50
PubMed score by year
PubTator Score 72.32
PubTator score by year
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Related Publications
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PMID
Year
Title