You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KANSL2
KAT8 regulatory NSL complex subunit 2

Protein Summary
Description
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000420613
  • ENSP00000415436
  • ENSG00000139620
  • ENST00000546701
  • ENSP00000448131

Symbol
  • C12orf41
  • NSL2
  • NSL2
  • C12orf41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.77
disease perturbation
0.74
transcription factor binding site profile
0.71
transcription factor perturbation
0.61
cellular component
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
KANSL1
Tbio
Novelty:  0.03032662
p_int:  0.999998633
p_ni:  0.000001367
Score:  0.992
Data Source:  BioPlex,STRINGDB
PHF20
Tbio
Family:  Epigenetic
Novelty:  0.01961423
p_int:  0.999995453
p_ni:  0.000004546
Score:  0.994
Data Source:  BioPlex,STRINGDB
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.9999706
p_ni:  0.000029381
p_wrong:  1.9e-8
Data Source:  BioPlex
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.999891642
p_ni:  0.000100596
p_wrong:  0.000007761
Data Source:  BioPlex
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999599611
p_ni:  0.000400256
p_wrong:  1.34e-7
Data Source:  BioPlex
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.999190634
p_ni:  0.000809353
p_wrong:  1.3e-8
Data Source:  BioPlex
NECAB1
Tbio
Novelty:  0.24384799
p_int:  0.999158882
p_ni:  0.00084111
p_wrong:  8e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
CSRNP1
Tbio
Novelty:  0.10538864
p_int:  0.993610657
p_ni:  0.00587315
p_wrong:  0.000516193
Data Source:  BioPlex
KANSL3
Tbio
Novelty:  0.00150009
Score:  0.987
Data Source:  STRINGDB
MCRS1
Tbio
Novelty:  0.03404119
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
47.7
leukocyte count
1
1
1
46.5
calcium measurement
1
1
1
40.7
heel bone mineral density
1
1
1
21.2
lymphocyte count
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
47.7
leukocyte count
1
46.5
calcium measurement
1
40.7
heel bone mineral density
1
21.2
lymphocyte count
1
12.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KAT8 regulatory NSL complex subunit 2
VGNC:5438
451865
Mouse
MGI:1916862
69612
Rat
RGD:1303127
300206
Dog
KAT8 regulatory NSL complex subunit 2
VGNC:42205
609028
Horse
KAT8 regulatory NSL complex subunit 2
VGNC:19237
100058626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KAT8 regulatory NSL complex subunit 2
Mouse
Rat
Dog
KAT8 regulatory NSL complex subunit 2
Horse
KAT8 regulatory NSL complex subunit 2
Publication Statistics
PubMed Score 11.09
PubMed score by year
PubTator Score 1.53
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title