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Tbio
KANSL1
KAT8 regulatory NSL complex subunit 1

Protein Summary
Description
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. This gene encodes a nuclear protein that is a subunit of two protein complexes involved with histone acetylation, the MLL1 complex and the NSL1 complex. The corresponding protein in Drosophila interacts with K(lysine) acetyltransferase 8, which is also a subunit of both the MLL1 and NSL1 complexes. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262419
  • ENSP00000262419
  • ENSG00000120071
  • ENST00000432791
  • ENSP00000387393
  • ENST00000572904
  • ENSP00000461484
  • ENST00000574590
  • ENSP00000461812

Symbol
  • CENP-36
  • KIAA1267
  • MSL1V1
  • NSL1
  • KDVS
  • NSL1
  • MSL1v1
  • CENP-36
  • hMSL1v1
  • KIAA1267
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
cellular component
0.78
interacting protein
0.77
virus perturbation
0.68
microRNA
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.46   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.46   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
PHF20
Tbio
Family:  Epigenetic
Novelty:  0.01961423
p_int:  1
Score:  0.992
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999988
p_ni:  1.2e-8
Score:  0.968
Data Source:  BioPlex,STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
p_int:  0.999999736
p_ni:  2.64e-7
Score:  0.296
Data Source:  BioPlex,STRINGDB
KANSL2
Tbio
Novelty:  0.08741608
p_int:  0.999998633
p_ni:  0.000001367
Score:  0.992
Data Source:  BioPlex,STRINGDB
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.999995617
p_ni:  0.000004383
Score:  0.239
Data Source:  BioPlex,STRINGDB
DUS2
Tbio
Family:  Enzyme
Novelty:  0.05121878
p_int:  0.999995416
p_ni:  0.000004452
p_wrong:  1.31e-7
Score:  0.369
Data Source:  BioPlex,STRINGDB
MCRS1
Tbio
Novelty:  0.03404119
p_int:  0.999943333
p_ni:  0.000056667
Score:  0.981
Data Source:  BioPlex,STRINGDB
FOXK2
Tbio
Family:  TF
Novelty:  0.01420141
p_int:  0.999383807
p_ni:  0.000616193
Score:  0.179
Data Source:  BioPlex,STRINGDB
ECI2
Tbio
Family:  Enzyme
Novelty:  0.02317646
p_int:  0.992135315
p_ni:  0.007864685
Score:  0.795
Data Source:  BioPlex,STRINGDB
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.906038662
p_ni:  0.093958344
p_wrong:  0.000002993
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (86)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
15
9
7
96.7
mean corpuscular volume
3
4
4
96.4
2
2
0
1.9
95.2
red blood cell distribution width
2
4
4
92.5
alcohol consumption measurement
6
6
6
92.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
9
7
96.7
mean corpuscular volume
4
96.4
0
1.9
95.2
red blood cell distribution width
4
92.5
alcohol consumption measurement
6
92.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
KAT8 regulatory NSL complex subunit 1
717172
Mouse
MGI:1923969
76719
Rat
RGD:1311429
360642
Dog
KAT8 regulatory NSL complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:24565]
Horse
KAT8 regulatory NSL complex subunit 1
VGNC:19235
100054597
Species
Name
OMA
EggNOG
Inparanoid
Macaque
KAT8 regulatory NSL complex subunit 1
Mouse
Rat
Dog
KAT8 regulatory NSL complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:24565]
Horse
KAT8 regulatory NSL complex subunit 1
Publication Statistics
PubMed Score 35.46
PubMed score by year
PubTator Score 20.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title