You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
KANK4
KN motif and ankyrin repeat domain-containing protein 4

Protein Summary
Description
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354381
  • ENSP00000346352
  • ENSG00000132854
  • ENST00000371153
  • ENSP00000360195

Symbol
  • ANKRD38
  • ANKRD38
  • dJ1078M7.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.65
tissue sample
0.61
microRNA
0.59
cell line
0.54
phenotype
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
TLN2
Tbio
Novelty:  0.0284423
p_int:  0.999999873
p_ni:  1.26e-7
p_wrong:  2e-9
Score:  0.361
Data Source:  BioPlex,STRINGDB
TRAPPC9
Tbio
Novelty:  0.02703008
p_int:  0.999994448
p_ni:  0.000005552
Score:  0.788
Data Source:  BioPlex,STRINGDB
C7orf43
Tdark
Novelty:  1.11975505
p_int:  0.999980385
p_ni:  0.000019614
Score:  0.816
Data Source:  BioPlex,STRINGDB
OSCP1
Tbio
Novelty:  0.05361924
p_int:  0.999962042
p_ni:  0.000037937
p_wrong:  2.2e-8
Score:  0.237
Data Source:  BioPlex,STRINGDB
TLN1
Tbio
Novelty:  0.00803981
p_int:  0.999942121
p_ni:  0.000057879
Score:  0.215
Data Source:  BioPlex,STRINGDB
TRAPPC10
Tbio
Novelty:  0.03433058
p_int:  0.999897787
p_ni:  0.000102213
Score:  0.741
Data Source:  BioPlex,STRINGDB
TRAPPC4
Tbio
Novelty:  0.05749912
p_int:  0.999176347
p_ni:  0.000823653
Score:  0.746
Data Source:  BioPlex,STRINGDB
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.991377416
p_ni:  0.008622577
p_wrong:  6e-9
Score:  0.675
Data Source:  BioPlex,STRINGDB
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.989131433
p_ni:  0.010868567
Score:  0.813
Data Source:  BioPlex,STRINGDB
TRAPPC3
Tbio
Novelty:  0.0360262
p_int:  0.970029287
p_ni:  0.029970713
Score:  0.811
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
1
3
3
82.2
total cholesterol measurement
1
3
3
79.1
1
1
0
2.1
62.1
low density lipoprotein cholesterol measurement
1
2
2
31.3
corneal topography
3
1
3
29.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
82.2
total cholesterol measurement
3
79.1
0
2.1
62.1
low density lipoprotein cholesterol measurement
2
31.3
corneal topography
3
29.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KN motif and ankyrin repeat domains 4
VGNC:1283
469206
Macaque
KN motif and ankyrin repeat domains 4
695040
Mouse
MGI:3043381
242553
Rat
RGD:1307635
313385
Dog
KN motif and ankyrin repeat domains 4
VGNC:42203
100684819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KN motif and ankyrin repeat domains 4
Macaque
KN motif and ankyrin repeat domains 4
Mouse
Rat
Dog
KN motif and ankyrin repeat domains 4
Publication Statistics
PubMed Score 4.03
PubMed score by year
PubTator Score 2.33
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title