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Tbio
KANK1
KN motif and ankyrin repeat domain-containing protein 1

Protein Summary
Description
Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration (PubMed:25961457). Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1 (PubMed:25961457). Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Regulates Rac signaling pathways (PubMed:25961457). The protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382293
  • ENSP00000371730
  • ENSG00000107104
  • ENST00000382297
  • ENSP00000371734
  • ENST00000382303
  • ENSP00000371740
  • ENST00000619269
  • ENSP00000477725

Symbol
  • ANKRD15
  • KANK
  • KIAA0172
  • KANK
  • CPSQ2
  • ANKRD15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
virus perturbation
0.9
histone modification site profile
0.82
PubMedID
0.77
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.06   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.06   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
ARRB2
Tbio
Novelty:  0.00148149
p_int:  0.999999642
p_ni:  3.58e-7
Score:  0.213
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999847553
p_ni:  0.000151832
p_wrong:  6.16e-7
Score:  0.206
Data Source:  BioPlex,STRINGDB
KIF21A
Tbio
Novelty:  0.01535562
Score:  0.986
Data Source:  STRINGDB
CXXC5
Tbio
Novelty:  0.00689893
Score:  0.908
Data Source:  STRINGDB
DOCK8
Tbio
Novelty:  0.0067047
Score:  0.904
Data Source:  STRINGDB
DMRT1
Tbio
Family:  TF
Novelty:  0.00403133
Score:  0.811
Data Source:  STRINGDB
SEPSECS
Tbio
Family:  Enzyme
Novelty:  0.00698701
Score:  0.8
Data Source:  STRINGDB
AP4M1
Tbio
Novelty:  0.00142961
Score:  0.731
Data Source:  STRINGDB
AP4E1
Tdark
Novelty:  0.09773225
Score:  0.729
Data Source:  STRINGDB
KIF21B
Tbio
Novelty:  0.06463481
Score:  0.675
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.5
83.4
2
3
0
1.1
82.5
fasting blood glucose measurement
2
2
2
70.4
mean platelet volume
1
1
1
62.1
1
1
0
1.7
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
83.4
0
1.1
82.5
fasting blood glucose measurement
2
70.4
mean platelet volume
1
62.1
0
1.7
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
KN motif and ankyrin repeat domains 1
697569
Mouse
MGI:2147707
107351
Rat
RGD:1307714
309429
Dog
KN motif and ankyrin repeat domains 1
VGNC:53727
100687276
Horse
KN motif and ankyrin repeat domains 1
100050757
Species
Name
OMA
EggNOG
Inparanoid
Macaque
KN motif and ankyrin repeat domains 1
Mouse
Rat
Dog
KN motif and ankyrin repeat domains 1
Horse
KN motif and ankyrin repeat domains 1
Publication Statistics
PubMed Score 55.06
PubMed score by year
PubTator Score 28.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title