Protein Summary
Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
- ENST00000240874
- ENSP00000240874
- ENSG00000160145
- ENST00000291478
- ENSP00000291478
- DUET
- DUO
- HAPIP
- TRAD
- DUO
- CHD5
- DUET
- TRAD
- CHDS5
- HAPIP
- ARHGEF24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
molecular function | 0.96 | ||
trait | 0.93 | ||
transcription factor perturbation | 0.88 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 158 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 113 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 158 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (246)
Nearest Tclin Targets
Pathways (21)
Reactome (17)
PathwayCommons (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
Death Receptor Signalling | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (6)
Components (4)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (31)
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 4 | 6 | 9 | 99.3 | |||||
platelet count | 2 | 4 | 4 | 94.3 | |||||
platelet crit | 2 | 2 | 2 | 90.4 | |||||
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 89.6 | |||||
6 | 3 | 4 | 1.1 | 75.4 | |||||
Items per page:
1 – 5 of 31
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 9 | 99.3 | |||||
platelet count | 4 | 94.3 | |||||
platelet crit | 2 | 90.4 | |||||
serum gamma-glutamyl transferase measurement | 2 | 89.6 | |||||
4 | 1.1 | 75.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | trio Rho guanine nucleotide exchange factor | 717492 | ||||||
Mouse | MGI:2685385 | 545156 | ||||||
Rat | RGD:621865 | 84009 | ||||||
Dog | kalirin RhoGEF kinase | VGNC:42200 | 478592 | |||||
Horse | kalirin RhoGEF kinase | VGNC:19234 | 100060560 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | trio Rho guanine nucleotide exchange factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | kalirin RhoGEF kinase | |||||
Horse | kalirin RhoGEF kinase | |||||
Publication Statistics
PubMed Score 113.00
PubMed score by year
PubTator Score 49.05
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (58)
GeneRif Annotations (30)
Items per page:
0 of 0
PMID | Year | Title |
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