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Tbio
JUNB
Transcription factor jun-B

Protein Summary
Description
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302754
  • ENSP00000303315
  • ENSG00000171223

Symbol
  • AP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.99
transcription factor binding site profile
0.98
PubMedID
0.96
biological process
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.95   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 835   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.95   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 835   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  1
Score:  0.997
Data Source:  BioPlex,STRINGDB
ATF2
Tbio
Family:  TF
Novelty:  0.00457832
p_int:  1
Score:  0.988
Data Source:  BioPlex,STRINGDB
BATF3
Tbio
Family:  TF
Novelty:  0.01554987
p_int:  1
Score:  0.876
Data Source:  BioPlex,STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
p_int:  0.99999998
p_ni:  1.8e-8
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CREB5
Tbio
Family:  TF
Novelty:  0.03857106
p_int:  0.999999947
p_ni:  5.2e-8
p_wrong:  1e-9
Score:  0.895
Data Source:  BioPlex,STRINGDB
ATF3
Tbio
Family:  TF
Novelty:  0.00164508
p_int:  0.999999909
p_ni:  4.9e-8
p_wrong:  4.2e-8
Score:  0.923
Data Source:  BioPlex,STRINGDB
ATF7
Tbio
Family:  TF
Novelty:  0.01470313
p_int:  0.9999998
p_ni:  1.98e-7
p_wrong:  2e-9
Score:  0.906
Data Source:  BioPlex,STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
p_int:  0.999999789
p_ni:  4.3e-8
p_wrong:  1.68e-7
Score:  0.424
Data Source:  BioPlex,STRINGDB
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.999999595
p_ni:  4.04e-7
p_wrong:  1e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
FOSB
Tbio
Family:  TF
Novelty:  0.00183071
p_int:  0.999998424
p_wrong:  0.000001576
Score:  0.992
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (145)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Interleukin-4 and Interleukin-13 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
5
5
97.8
reticulocyte measurement
3
4
5
97.2
mean corpuscular hemoglobin concentration
3
3
3
97
reticulocyte count
7
3
7
94.2
erythrocyte count
3
3
3
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
97.8
reticulocyte measurement
5
97.2
mean corpuscular hemoglobin concentration
3
97
reticulocyte count
7
94.2
erythrocyte count
3
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
JunB proto-oncogene, AP-1 transcription factor subunit
VGNC:7559
468739
Macaque
JunB proto-oncogene, AP-1 transcription factor subunit
717837
Mouse
MGI:96647
16477
Rat
RGD:2944
24517
Dog
JunB proto-oncogene, AP-1 transcription factor subunit
VGNC:42198
100856456
Species
Name
OMA
EggNOG
Inparanoid
Chimp
JunB proto-oncogene, AP-1 transcription factor subunit
Macaque
JunB proto-oncogene, AP-1 transcription factor subunit
Mouse
Rat
Dog
JunB proto-oncogene, AP-1 transcription factor subunit
Publication Statistics
PubMed Score 89.95
PubMed score by year
PubTator Score 1270.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title