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Tbio
JTB
Protein JTB

Protein Summary
Description
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271843
  • ENSP00000271843
  • ENSG00000143543
  • ENST00000356648
  • ENSP00000349069
  • ENST00000368589
  • ENSP00000357578
  • ENST00000428469
  • ENSP00000395250

Symbol
  • PAR
  • hJT
  • HJTB
  • HSPC222
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.99
kinase perturbation
0.91
virus perturbation
0.83
tissue
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.11   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.11   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
TMEM120B
Tdark
Novelty:  1.46242586
p_int:  0.999849769
p_ni:  0.000150228
p_wrong:  3e-9
Data Source:  BioPlex
PIGQ
Tbio
Family:  Enzyme
Novelty:  0.02701629
p_int:  0.999768747
p_ni:  0.000224843
p_wrong:  0.00000641
Data Source:  BioPlex
MIPEP
Tbio
Family:  Enzyme
Novelty:  0.01507033
p_int:  0.999567031
p_ni:  0.000432969
Data Source:  BioPlex
ATRIP
Tbio
Novelty:  0.01415267
p_int:  0.999293445
p_ni:  0.000706517
p_wrong:  3.8e-8
Data Source:  BioPlex
UTP20
Tbio
Novelty:  0.09170451
p_int:  0.998927541
p_ni:  0.001072458
Data Source:  BioPlex
NDC1
Tbio
Novelty:  0.15840853
p_int:  0.998866557
p_ni:  0.001133442
p_wrong:  1e-9
Data Source:  BioPlex
STEAP3
Tbio
Family:  Enzyme
Novelty:  0.02042104
p_int:  0.998847701
p_ni:  0.001152281
p_wrong:  1.8e-8
Data Source:  BioPlex
TMEM120A
Tdark
Novelty:  0.21664358
p_int:  0.998054038
p_ni:  0.001710722
p_wrong:  0.00023524
Data Source:  BioPlex
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.997936041
p_ni:  0.002063956
p_wrong:  2e-9
Data Source:  BioPlex
DNM1L
Tchem
Novelty:  0.00151314
p_int:  0.997861319
p_ni:  0.00213787
p_wrong:  8.12e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
74.8
platelet count
1
1
1
72.9
age at first birth measurement
2
2
2
72.4
body height
1
1
1
60.2
C-reactive protein measurement
2
2
2
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
74.8
platelet count
1
72.9
age at first birth measurement
2
72.4
body height
1
60.2
C-reactive protein measurement
2
58.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
jumping translocation breakpoint
457342
Macaque
jumping translocation breakpoint
718537
Mouse
MGI:1346082
23922
Rat
RGD:2942
29439
Cow
jumping translocation breakpoint
513970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
jumping translocation breakpoint
Macaque
jumping translocation breakpoint
Mouse
Rat
Cow
jumping translocation breakpoint
Publication Statistics
PubMed Score 13.11
PubMed score by year
PubTator Score 140.06
PubTator score by year
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Related Publications
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PMID
Year
Title