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Tdark
JSRP1
Junctional sarcoplasmic reticulum protein 1

Protein Summary
Description
Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity. The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux in skeletal muscle. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300961
  • ENSP00000300961
  • ENSG00000167476

Symbol
  • JP45
  • JP45
  • JP-45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.71
tissue sample
0.66
cell line
0.47
tissue
0.47
metabolite
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
SIAH1
Tbio
Family:  Enzyme
Novelty:  0.00831224
p_int:  0.999990203
p_ni:  0.000009762
p_wrong:  3.5e-8
Score:  0.313
Data Source:  BioPlex,STRINGDB
AHNAK
Tbio
Novelty:  0.01201996
p_int:  0.967347924
p_ni:  0.032652076
Score:  0.507
Data Source:  BioPlex,STRINGDB
AHNAK2
Tbio
Novelty:  0.05663435
p_int:  0.929800011
p_ni:  0.070199989
Score:  0.303
Data Source:  BioPlex,STRINGDB
GNAO1
Tbio
Novelty:  0.00315097
p_int:  0.897440548
p_ni:  0.102557953
p_wrong:  0.000001499
Score:  0.188
Data Source:  BioPlex,STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
p_int:  0.792706174
p_ni:  0.207284039
p_wrong:  0.000009787
Score:  0.211
Data Source:  BioPlex,STRINGDB
CACNA1S
Tclin
Family:  IC
Novelty:  0.00434282
Score:  0.881
Data Source:  STRINGDB
RWDD2B
Tdark
Novelty:  0.42452529
Score:  0.7
Data Source:  STRINGDB
UBN2
Tbio
Novelty:  0.09777456
Score:  0.682
Data Source:  STRINGDB
SRL
Tdark
Novelty:  0.03172682
Score:  0.627
Data Source:  STRINGDB
SYPL2
Tdark
Novelty:  0.03928948
Score:  0.598
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
6
6
6
98
hemoglobin measurement
5
5
5
97.7
BMI-adjusted hip circumference
3
10
12
96.1
body height
4
4
4
93.1
red blood cell density measurement
2
2
2
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
6
98
hemoglobin measurement
5
97.7
BMI-adjusted hip circumference
12
96.1
body height
4
93.1
red blood cell density measurement
2
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1916700
71912
Rat
RGD:1596084
690423
Cow
junctional sarcoplasmic reticulum protein 1
VGNC:50101
509378
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
junctional sarcoplasmic reticulum protein 1
Publication Statistics
PubMed Score 12.84
PubMed score by year
PubTator Score 2.75
PubTator score by year
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Related Publications
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PMID
Year
Title