Protein Summary
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
- ENST00000356300
- ENSP00000348648
- ENSG00000092051
- ENST00000397118
- ENSP00000380307
- JPHL1
- KIAA1831
- JP4
- JPHL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.63 | ||
biological process | 0.56 | ||
cell line | 0.56 | ||
gene perturbation | 0.56 | ||
tissue sample | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.92 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.92 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (94)
MYO10
Novelty: 0.0233015
p_int: 0.999999697
p_ni: 3.02e-7
Score: 0.248
Data Source: BioPlex,STRINGDB
PPP1R12C
Family: Enzyme
Novelty: 0.00465397
p_int: 0.999998841
p_ni: 4.3e-8
p_wrong: 0.000001116
Score: 0.159
Data Source: BioPlex,STRINGDB
MPRIP
Family: Enzyme
Novelty: 0.03253403
p_int: 0.999993099
p_ni: 0.000006901
Data Source: BioPlex
ZSWIM8
Novelty: 0.26740136
p_int: 0.999972308
p_ni: 0.00002769
p_wrong: 2e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (1)
Components (8)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 2 | 1 | 2 | 49.5 | |||||
resting heart rate | 1 | 1 | 0 | 7.4 | 17.8 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 2 | 49.5 | |||||
resting heart rate | 0 | 7.4 | 17.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | junctophilin 4 | VGNC:12847 | 467408 | |||||
Mouse | MGI:2443113 | 319984 | ||||||
Rat | RGD:1303170 | 445271 | ||||||
Cow | junctophilin 4 | VGNC:30383 | 781073 | |||||
Pig | junctophilin 4 | 100152448 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | junctophilin 4 | |||||
Mouse | ||||||
Rat | ||||||
Cow | junctophilin 4 | |||||
Pig | junctophilin 4 | |||||
Publication Statistics
PubMed Score 19.92
PubMed score by year
PubTator Score 22.03
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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