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Tbio
JPH4
Junctophilin-4

Protein Summary
Description
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). This gene encodes a member of the junctophilin family of transmembrane proteins that are involved in the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum in excitable cells. The encoded protein contains a conserved N-terminal repeat region called the membrane occupation and recognition nexus sequence that is found in other members of the junctophilin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356300
  • ENSP00000348648
  • ENSG00000092051
  • ENST00000397118
  • ENSP00000380307

Symbol
  • JPHL1
  • KIAA1831
  • JP4
  • JPHL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.63
biological process
0.56
cell line
0.56
gene perturbation
0.56
tissue sample
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
ARHGAP29
Tbio
Family:  Enzyme
Novelty:  0.05574918
p_int:  1
Score:  0.179
Data Source:  BioPlex,STRINGDB
GCC1
Tbio
Novelty:  0.0844824
p_int:  0.999999917
p_ni:  9e-9
p_wrong:  7.4e-8
Data Source:  BioPlex
RAD18
Tbio
Family:  Enzyme
Novelty:  0.00519213
p_int:  0.999999736
p_ni:  2.64e-7
Data Source:  BioPlex
MYO10
Tbio
Novelty:  0.0233015
p_int:  0.999999697
p_ni:  3.02e-7
Score:  0.248
Data Source:  BioPlex,STRINGDB
UACA
Tbio
Novelty:  0.05853699
p_int:  0.999999478
p_ni:  5.12e-7
p_wrong:  1e-8
Data Source:  BioPlex
TRIOBP
Tbio
Novelty:  0.04145641
p_int:  0.999999259
p_ni:  7.4e-7
Data Source:  BioPlex
PPP1R12C
Tdark
Family:  Enzyme
Novelty:  0.00465397
p_int:  0.999998841
p_ni:  4.3e-8
p_wrong:  0.000001116
Score:  0.159
Data Source:  BioPlex,STRINGDB
MPRIP
Tbio
Family:  Enzyme
Novelty:  0.03253403
p_int:  0.999993099
p_ni:  0.000006901
Data Source:  BioPlex
UBE2O
Tbio
Novelty:  0.07084123
p_int:  0.999983728
p_ni:  0.000016272
Data Source:  BioPlex
ZSWIM8
Tdark
Novelty:  0.26740136
p_int:  0.999972308
p_ni:  0.00002769
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
1
2
49.5
resting heart rate
1
1
0
7.4
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
49.5
resting heart rate
0
7.4
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
junctophilin 4
VGNC:12847
467408
Mouse
MGI:2443113
319984
Rat
RGD:1303170
445271
Cow
junctophilin 4
VGNC:30383
781073
Pig
junctophilin 4
100152448
Species
Name
OMA
EggNOG
Inparanoid
Chimp
junctophilin 4
Mouse
Rat
Cow
junctophilin 4
Pig
junctophilin 4
Publication Statistics
PubMed Score 19.92
PubMed score by year
PubTator Score 22.03
PubTator score by year
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Related Publications
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PMID
Year
Title