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Tbio
JPH1
Junctophilin-1

Protein Summary
Description
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. [ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342232
  • ENSP00000344488
  • ENSG00000104369

Symbol
  • JP1
  • JP1
  • JP-1
  • CMT2K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
PubMedID
0.69
gene perturbation
0.68
cellular component
0.63
microRNA
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.95   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.95   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
ARHGAP26
Tbio
Family:  Enzyme
Novelty:  0.02409941
p_int:  0.999954778
p_ni:  0.000045222
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
SCYL3
Tbio
Family:  Kinase
Novelty:  0.13735583
p_int:  0.999924893
p_ni:  0.000075107
Data Source:  BioPlex
TRDN
Tbio
Novelty:  0.00501554
p_int:  0.999633518
p_ni:  0.000366478
p_wrong:  4e-9
Score:  0.832
Data Source:  BioPlex,STRINGDB
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.99885728
p_ni:  0.00114272
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.994282554
p_ni:  0.005717446
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.98586716
p_ni:  0.014129467
p_wrong:  0.000003373
Data Source:  BioPlex
TNFRSF19
Tbio
Novelty:  0.01295599
p_int:  0.983251673
p_ni:  0.016745659
p_wrong:  0.000002668
Data Source:  BioPlex
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.971457775
p_ni:  0.028542224
p_wrong:  1e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
RTN2
Tbio
Novelty:  0.05184418
p_int:  0.955285655
p_ni:  0.044714312
p_wrong:  3.3e-8
Score:  0.342
Data Source:  BioPlex,STRINGDB
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.95445248
p_ni:  0.04553811
p_wrong:  0.000009409
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
junctophilin 1
VGNC:858
472796
Mouse
MGI:1891495
57339
Rat
RGD:1308789
297748
Dog
junctophilin 1
VGNC:42194
487001
Horse
junctophilin 1
VGNC:19227
100051011
Species
Name
OMA
EggNOG
Inparanoid
Chimp
junctophilin 1
Mouse
Rat
Dog
junctophilin 1
Horse
junctophilin 1
Publication Statistics
PubMed Score 108.95
PubMed score by year
PubTator Score 11.04
PubTator score by year
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Related Publications
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PMID
Year
Title