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Tbio
JMJD8
JmjC domain-containing protein 8

Protein Summary
Description
Functions as a positive regulator of TNF-induced NF-kappa-B signaling (PubMed:27671354). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000562824
  • ENSP00000454358
  • ENSG00000161999
  • ENST00000609261
  • ENSP00000477481

Symbol
  • C16orf20
  • PP14397
  • C16orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.78
transcription factor
0.64
cell line
0.62
tissue sample
0.58
tissue
0.5


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.52   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.52   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
PDIA3
Tbio
Family:  Enzyme
Novelty:  0.00285939
p_int:  0.999969903
p_ni:  0.000029233
p_wrong:  8.64e-7
Score:  0.375
Data Source:  BioPlex,STRINGDB
A4GNT
Tbio
Family:  Enzyme
Novelty:  0.08971876
p_int:  0.9997938
p_ni:  0.000206196
p_wrong:  4e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.999483461
p_ni:  0.000514451
p_wrong:  0.000002088
Data Source:  BioPlex
CDHR5
Tbio
Novelty:  0.08525208
p_int:  0.999234808
p_ni:  0.000763489
p_wrong:  0.000001703
Score:  0.157
Data Source:  BioPlex,STRINGDB
WNT10B
Tbio
Novelty:  0.00503163
p_int:  0.99918944
p_ni:  0.000810547
p_wrong:  1.3e-8
Score:  0.241
Data Source:  BioPlex,STRINGDB
ASTL
Tbio
Family:  Enzyme
Novelty:  0.02265035
p_int:  0.999118002
p_ni:  0.000881994
p_wrong:  4e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
TXNDC5
Tbio
Novelty:  0.02369481
p_int:  0.997458653
p_ni:  0.001344519
p_wrong:  0.001196828
Score:  0.274
Data Source:  BioPlex,STRINGDB
PLD6
Tbio
Family:  Enzyme
Novelty:  0.02802141
p_int:  0.996656661
p_ni:  0.000656764
p_wrong:  0.002686575
Data Source:  BioPlex
PDIA6
Tchem
Family:  Enzyme
Novelty:  0.01692178
p_int:  0.995306145
p_ni:  0.00368769
p_wrong:  0.001006165
Score:  0.201
Data Source:  BioPlex,STRINGDB
ASGR2
Tbio
Novelty:  0.14671716
p_int:  0.992257916
p_ni:  0.006967649
p_wrong:  0.000774435
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
10
11
91.8
mean corpuscular volume
1
1
1
84
BMI-adjusted waist circumference
1
7
7
82.8
mean reticulocyte volume
1
2
2
81.8
cancer antigen 125 measurement
1
3
3
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
11
91.8
mean corpuscular volume
1
84
BMI-adjusted waist circumference
7
82.8
mean reticulocyte volume
2
81.8
cancer antigen 125 measurement
3
77.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
jumonji domain containing 8
697226
Mouse
MGI:1919356
72106
Rat
RGD:1307381
360498
Dog
jumonji domain containing 8
VGNC:42190
490091
Horse
jumonji domain containing 8
VGNC:19224
100147047
Species
Name
OMA
EggNOG
Inparanoid
Macaque
jumonji domain containing 8
Mouse
Rat
Dog
jumonji domain containing 8
Horse
jumonji domain containing 8
Publication Statistics
PubMed Score 5.52
PubMed score by year
PubTator Score 1.38
PubTator score by year
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Related Publications
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PMID
Year
Title