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Tbio
JMJD8
JmjC domain-containing protein 8

Protein Summary
Description
Functions as a positive regulator of TNF-induced NF-kappa-B signaling (PubMed:27671354). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000562824
  • ENSP00000454358
  • ENSG00000161999
  • ENST00000609261
  • ENSP00000477481

Symbol
  • C16orf20
  • PP14397
  • C16orf20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.78
transcription factor
0.64
cell line
0.62
tissue sample
0.58
tissue
0.5


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0