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Tchem
JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

Protein Summary
Description
Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splici ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397625
  • ENSP00000380750
  • ENSG00000070495
  • ENST00000445478
  • ENSP00000394085

Symbol
  • KIAA0585
  • PTDSR
  • PSR
  • PTDSR
  • PTDSR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
phenotype
0.9
molecular function
0.86
biological process
0.84
virus perturbation
0.83


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.41   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 339.41   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (156)
PRPF40A
Tbio
Novelty:  0.00898047
p_int:  1
Score:  0.553
Data Source:  BioPlex,STRINGDB
AKAP17A
Tbio
Family:  Enzyme
Novelty:  0.02860381
p_int:  1
Data Source:  BioPlex
RSRC1
Tbio
Novelty:  0.12148079
p_int:  0.999999997
p_ni:  3e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
LUC7L
Tbio
Novelty:  0.05748021
p_int:  0.999999991
p_ni:  9e-9
Score:  0.318
Data Source:  BioPlex,STRINGDB
PHRF1
Tbio
Family:  Epigenetic
Novelty:  0.05250013
p_int:  0.99999998
p_ni:  6e-9
p_wrong:  1.4e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
DDX46
Tbio
Family:  Enzyme
Novelty:  0.02888527
p_int:  0.999999959
p_ni:  4e-8
p_wrong:  1e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.999999877
p_ni:  1.23e-7
Score:  0.361
Data Source:  BioPlex,STRINGDB
SREK1
Tbio
Novelty:  0.19228162
p_int:  0.99999981
p_ni:  1.9e-7
Score:  0.61
Data Source:  BioPlex,STRINGDB
PRPF38B
Tdark
Novelty:  1.02626586
p_int:  0.999999805
p_ni:  1.93e-7
p_wrong:  2e-9
Score:  0.535
Data Source:  BioPlex,STRINGDB
DHX8
Tbio
Family:  Enzyme
Novelty:  0.01584745
p_int:  0.999999653
p_ni:  3.47e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
63.7
pulse pressure measurement
1
1
1
51.7
mathematical ability
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
63.7
pulse pressure measurement
1
51.7
mathematical ability
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginine demethylase and lysine hydroxylase
VGNC:10048
468338
Macaque
arginine demethylase and lysine hydroxylase
720764
Mouse
MGI:1858910
107817
Rat
RGD:1305395
360665
Dog
arginine demethylase and lysine hydroxylase
VGNC:42189
100856152
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginine demethylase and lysine hydroxylase
Macaque
arginine demethylase and lysine hydroxylase
Mouse
Rat
Dog
arginine demethylase and lysine hydroxylase
Publication Statistics
PubMed Score 339.41
PubMed score by year
PubTator Score 125.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title