Tbio JCHAIN Immunoglobulin J chain

Protein Summary

Description

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Uniprot Accession IDs

• P01591

Gene Name

• JCHAIN

Ensembl ID

• ENST00000254801
• ENSP00000254801
• ENSG00000132465
• ENST00000510437
• ENSP00000426687
• ENST00000543780
• ENSP00000440066

Symbol

• IGCJ
• IGJ
• IGJ
• JCH
• IGCJ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
small molecule perturbation	0.84
cellular component	0.67
phenotype	0.63
disease	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 623.31   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 309   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 623.31   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0