Tbio JCHAIN Immunoglobulin J chain

Protein Summary

Description

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Uniprot Accession IDs

• P01591

Gene Name

• JCHAIN

Ensembl ID

• ENST00000254801
• ENSP00000254801
• ENSG00000132465
• ENST00000510437
• ENSP00000426687
• ENST00000543780
• ENSP00000440066

Symbol

• IGCJ
• IGJ
• IGJ
• JCH
• IGCJ

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
small molecule perturbation	0.84
cellular component	0.67
phenotype	0.63
disease	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.61   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 309   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.61   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (80)

Explore Interacting Targets

1 – 10 of 80

• See Interactions on String-DB

FRMD1

Tdark

Novelty:  0.96833141

p_int:  0.998637205

p_ni:  0.001178031

p_wrong:  0.000184765

Data Source:  BioPlex

ZNF491

Tdark

Family:  TF

Novelty:  4.75862069

p_int:  0.997020564

p_ni:  0.000957674

p_wrong:  0.002021762

Score:  0.181

Data Source:  BioPlex,STRINGDB

COG2

Tbio

Novelty:  0.03109287

p_int:  0.996863202

p_ni:  0.002194493

p_wrong:  0.000942305

Data Source:  BioPlex

HBM

Tdark

Novelty:  0.02658671

p_int:  0.996727477

p_ni:  0.001247667

p_wrong:  0.002024856

Data Source:  BioPlex

SNW1

Tbio

Novelty:  0.01423797

p_int:  0.996712077

p_ni:  0.002849658

p_wrong:  0.000438265

Data Source:  BioPlex

DDX31

Tbio

Family:  Enzyme

Novelty:  2.84646195

p_int:  0.996632714

p_ni:  0.001316829

p_wrong:  0.002050457

Data Source:  BioPlex

JAK2

Tclin

Family:  Kinase

Novelty:  0.00022894

p_int:  0.996318536

p_ni:  0.002617062

p_wrong:  0.001064402

Data Source:  BioPlex

TMEM237

Tdark

Novelty:  0.27005874

p_int:  0.996213586

p_ni:  0.001541811

p_wrong:  0.002244603

Score:  0.28

Data Source:  BioPlex,STRINGDB

APCDD1

Tbio

Novelty:  0.25122542

p_int:  0.995448

p_ni:  0.003142637

p_wrong:  0.001409363

Score:  0.188

Data Source:  BioPlex,STRINGDB

RHOBTB1

Tbio

Novelty:  0.02152609

p_int:  0.993773245

p_ni:  0.006203008

p_wrong:  0.000023747

Score:  0.179

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (5)

Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Scavenging of heme from plasma	87 targets	R-HSA-2168880
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Hemostasis	666 targets	R-HSA-109582
Scavenging of heme from plasma	87 targets	R-HSA-2168880
Vesicle-mediated transport	725 targets	R-HSA-5653656

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (5)

Components (9)

Processes (10)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
protein homodimerization activity	Inferred from Direct Assay (IDA)	UniProtKB
IgA binding	Inferred from Mutant Phenotype (IMP)	UniProtKB
immunoglobulin receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
antigen binding	Non-traceable Author Statement (NAS)	UniProtKB
protein binding, bridging	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body fat percentage	EFO_0007800	1	1	1		14.2
serum metabolite measurement	EFO_0005653	1	1	1		8.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body fat percentage	EFO_0007800	1		14.2
serum metabolite measurement	EFO_0005653	1		8.4

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
body fat percentage
serum metabolite measurement

MGI Phenotype Find Similar Targets

No Header	No Header
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	joining chain of multimeric IgA and IgM	VGNC:622	461276
Mouse	immunoglobulin joining chain	MGI:96493	16069
Rat	Immunoglobulin J chain [Source:UniProtKB/Swiss-Prot;Acc:P01592]
Dog	joining chain of multimeric IgA and IgM	VGNC:42184	475166
Horse	joining chain of multimeric IgA and IgM	VGNC:19219	100629603

Species	Name	OMA	EggNOG	Inparanoid
Chimp	joining chain of multimeric IgA and IgM
Mouse	immunoglobulin joining chain
Rat	Immunoglobulin J chain [Source:UniProtKB/Swiss-Prot;Acc:P01592]
Dog	joining chain of multimeric IgA and IgM
Horse	joining chain of multimeric IgA and IgM

Publication Statistics

PubMed Score 574.61

PubMed score by year

Reset Zoom

PubTator Score 213.34

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (41)

GeneRif Annotations (3)

Items per page:

10

0 of 0

PMID	Year	Title