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Tbio
JCHAIN
Immunoglobulin J chain

Protein Summary
Description
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254801
  • ENSP00000254801
  • ENSG00000132465
  • ENST00000510437
  • ENSP00000426687
  • ENST00000543780
  • ENSP00000440066

Symbol
  • IGCJ
  • IGJ
  • IGJ
  • JCH
  • IGCJ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
small molecule perturbation
0.84
cellular component
0.67
phenotype
0.63
disease
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.61   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.61   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.998637205
p_ni:  0.001178031
p_wrong:  0.000184765
Data Source:  BioPlex
ZNF491
Tdark
Family:  TF
Novelty:  4.75862069
p_int:  0.997020564
p_ni:  0.000957674
p_wrong:  0.002021762
Score:  0.181
Data Source:  BioPlex,STRINGDB
COG2
Tbio
Novelty:  0.03109287
p_int:  0.996863202
p_ni:  0.002194493
p_wrong:  0.000942305
Data Source:  BioPlex
HBM
Tdark
Novelty:  0.02658671
p_int:  0.996727477
p_ni:  0.001247667
p_wrong:  0.002024856
Data Source:  BioPlex
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.996712077
p_ni:  0.002849658
p_wrong:  0.000438265
Data Source:  BioPlex
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.996632714
p_ni:  0.001316829
p_wrong:  0.002050457
Data Source:  BioPlex
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
p_int:  0.996318536
p_ni:  0.002617062
p_wrong:  0.001064402
Data Source:  BioPlex
TMEM237
Tdark
Novelty:  0.27005874
p_int:  0.996213586
p_ni:  0.001541811
p_wrong:  0.002244603
Score:  0.28
Data Source:  BioPlex,STRINGDB
APCDD1
Tbio
Novelty:  0.25122542
p_int:  0.995448
p_ni:  0.003142637
p_wrong:  0.001409363
Score:  0.188
Data Source:  BioPlex,STRINGDB
RHOBTB1
Tbio
Novelty:  0.02152609
p_int:  0.993773245
p_ni:  0.006203008
p_wrong:  0.000023747
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Scavenging of heme from plasma
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Cell surface interactions at the vascular wall
Hemostasis
Scavenging of heme from plasma
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
1
1
14.2
serum metabolite measurement
1
1
1
8.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
14.2
serum metabolite measurement
1
8.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
joining chain of multimeric IgA and IgM
VGNC:622
461276
Mouse
MGI:96493
16069
Rat
Dog
joining chain of multimeric IgA and IgM
VGNC:42184
475166
Horse
joining chain of multimeric IgA and IgM
VGNC:19219
100629603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
joining chain of multimeric IgA and IgM
Mouse
Rat
Dog
joining chain of multimeric IgA and IgM
Horse
joining chain of multimeric IgA and IgM
Publication Statistics
PubMed Score 574.61
PubMed score by year
PubTator Score 213.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title