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Tclin
JAK2
Tyrosine-protein kinase JAK2

Protein Summary
Description
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during eryt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381652
  • ENSP00000371067
  • ENSG00000096968

Symbol
  • JTK10
  • THCYT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
molecular function
1
protein domain
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4609.88   (req: < 5)
Gene RIFs: 1154   (req: <= 3)
Antibodies: 1068   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4609.88   (req: >= 5)
Gene RIFs: 1154   (req: > 3)
Antibodies: 1068   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 100
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2703
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (10)
nintedanib
Rendered image for nintedanib
fedratinib
Rendered image for fedratinib
crizotinib
Rendered image for crizotinib
entrectinib
Rendered image for entrectinib
baricitinib
Rendered image for baricitinib
ruxolitinib
Rendered image for ruxolitinib
tofacitinib
Rendered image for tofacitinib
upadacitinib
Rendered image for upadacitinib
filgotinib
Rendered image for filgotinib
delgocitinib
Rendered image for delgocitinib
Protein-Protein Interactions (510)
ARHGAP18
Tbio
Family:  Enzyme
Novelty:  0.10618156
p_int:  0.999999954
p_ni:  4.2e-8
p_wrong:  4e-9
Data Source:  BioPlex
UBP1
Tbio
Family:  TF
Novelty:  0.01140885
p_int:  0.999988525
p_ni:  0.000011455
p_wrong:  1.9e-8
Score:  0.248
Data Source:  BioPlex,STRINGDB
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.999970672
p_ni:  0.000029287
p_wrong:  4.1e-8
Data Source:  BioPlex
JCHAIN
Tbio
Novelty:  0.00172454
p_int:  0.996318536
p_ni:  0.002617062
p_wrong:  0.001064402
Data Source:  BioPlex
CST2
Tbio
Novelty:  0.02114441
p_int:  0.99388002
p_ni:  0.00565309
p_wrong:  0.00046689
Data Source:  BioPlex
MUC5B
Tbio
Novelty:  0.000832
p_int:  0.977118355
p_ni:  0.022784996
p_wrong:  0.000096649
Score:  0.218
Data Source:  BioPlex,STRINGDB
PBK
Tchem
Family:  Kinase
Novelty:  0.00278659
p_int:  0.972265733
p_ni:  0.024740383
p_wrong:  0.002993884
Data Source:  BioPlex
HMMR
Tchem
Novelty:  0.0039196
p_int:  0.969523402
p_ni:  0.030472622
p_wrong:  0.000003976
Data Source:  BioPlex
IGHA2
Tbio
p_int:  0.906900853
p_ni:  0.093056652
p_wrong:  0.000042495
Data Source:  BioPlex
MUC7
Tbio
Novelty:  0.00750654
p_int:  0.895337304
p_ni:  0.000011269
p_wrong:  0.104651427
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (191)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Cyclin D associated events in G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Chromatin modifying enzymes
Chromatin organization
Cyclin D associated events in G1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (113)
Find Similar Targets
Items per page:
10
1 – 10 of 21
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
CACAO
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
8
10
49.9
99.2
platelet crit
2
6
8
99.1
3
3
0
2
97.7
eosinophil count
2
3
3
95.1
eosinophil percentage of leukocytes
2
3
3
93.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
10
49.9
99.2
platelet crit
8
99.1
0
2
97.7
eosinophil count
3
95.1
eosinophil percentage of leukocytes
3
93.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Janus kinase 2
VGNC:4770
464979
Macaque
Janus kinase 2
694184
Mouse
MGI:96629
16452
Rat
RGD:2939
24514
Dog
Janus kinase 2
VGNC:42176
484185
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Janus kinase 2
Macaque
Janus kinase 2
Mouse
Rat
Dog
Janus kinase 2
Publication Statistics
PubMed Score 4609.88
PubMed score by year
PubTator Score 3880.39
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title