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Tclin
JAK1
Tyrosine-protein kinase JAK1

Protein Summary
Description
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529). This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342505
  • ENSP00000343204
  • ENSG00000162434

Symbol
  • JAK1A
  • JAK1B
  • JTK3
  • JAK1A
  • JAK1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
protein domain
1
virus perturbation
1
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 987.96   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 565   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 987.96   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 565   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3037
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
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The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (9)
sunitinib
Rendered image for sunitinib
nintedanib
Rendered image for nintedanib
fedratinib
Rendered image for fedratinib
baricitinib
Rendered image for baricitinib
ruxolitinib
Rendered image for ruxolitinib
tofacitinib
Rendered image for tofacitinib
upadacitinib
Rendered image for upadacitinib
filgotinib
Rendered image for filgotinib
delgocitinib
Rendered image for delgocitinib
Protein-Protein Interactions (363)
IFNLR1
Tbio
Novelty:  0.01990628
p_int:  0.999980493
p_ni:  0.000019507
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
IL4R
Tclin
Novelty:  0.00359183
p_int:  0.998786542
p_ni:  0.001213458
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
OSMR
Tbio
Novelty:  0.01554974
p_int:  0.97650127
p_ni:  0.02349873
Score:  0.962
Data Source:  BioPlex,Reactome,STRINGDB
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
p_int:  0.974123871
p_ni:  0.025876129
Score:  0.241
Data Source:  BioPlex,STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.959319667
p_ni:  0.040680333
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.955405947
p_ni:  0.044594053
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.952606992
p_ni:  0.047393008
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.946287365
p_ni:  0.053712635
Score:  0.855
Data Source:  BioPlex,STRINGDB
IFNGR1
Tbio
Novelty:  0.00417244
p_int:  0.89478986
p_ni:  0.10521014
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.893939132
p_ni:  0.106060868
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (149)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Find Similar Targets
Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
ISG15 antiviral mechanism
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
FLT3 Signaling
IL-6-type cytokine receptor ligand interactions
ISG15 antiviral mechanism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
6
94.7
eosinophil percentage of leukocytes
2
3
4
93.8
lymphocyte count
2
2
2
81.1
C-reactive protein measurement
2
3
3
78.6
1
1
0
1.2
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
6
94.7
eosinophil percentage of leukocytes
4
93.8
lymphocyte count
2
81.1
C-reactive protein measurement
3
78.6
0
1.2
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Janus kinase 1
VGNC:1281
743373
Macaque
Janus kinase 1
677689
Mouse
MGI:96628
16451
Rat
RGD:69056
84598
Dog
Janus kinase 1
VGNC:42175
442952
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Janus kinase 1
Macaque
Janus kinase 1
Mouse
Rat
Dog
Janus kinase 1
Publication Statistics
PubMed Score 987.96
PubMed score by year
PubTator Score 723.39
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title