Tbio JAG2 Protein jagged-2

Protein Summary

Description

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9Y219
• Q9UE17
• Q9UE99
• Q9UNK8
• Q9Y6P9
• Q9Y6Q0
• Jagged2

Gene Name

• JAG2

Ensembl ID

• ENST00000331782
• ENSP00000328169
• ENSG00000184916
• ENST00000347004
• ENSP00000328566

Symbol

• HJ2
• SER2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
disease perturbation	0.87
kinase perturbation	0.84
PubMedID	0.75
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.63   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 444   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.63   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 444   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (138)

Explore Interacting Targets

1 – 10 of 138

• See Interactions on String-DB

VASN

Tbio

Novelty:  0.05424159

p_int:  0.99998421

p_ni:  0.000015567

p_wrong:  2.23e-7

Score:  0.164

Data Source:  BioPlex,STRINGDB

TMEM30B

Tbio

Novelty:  0.26735006

p_int:  0.999610293

p_ni:  0.000389707

Data Source:  BioPlex

PLPPR1

Tdark

Family:  Enzyme

Novelty:  0.38109551

p_int:  0.998086974

p_ni:  0.00191302

p_wrong:  6e-9

Score:  0.214

Data Source:  BioPlex,STRINGDB

TCTN2

Tbio

Novelty:  0.11617528

p_int:  0.997757763

p_ni:  0.002242216

p_wrong:  2.1e-8

Data Source:  BioPlex

STS

Tchem

Family:  Enzyme

Novelty:  0.00324549

p_int:  0.997541032

p_ni:  0.00245894

p_wrong:  2.7e-8

Score:  0.179

Data Source:  BioPlex,STRINGDB

ADAM32

Tdark

Family:  Enzyme

Novelty:  0.36071191

p_int:  0.982252907

p_ni:  0.017206138

p_wrong:  0.000540956

Score:  0.216

Data Source:  BioPlex,STRINGDB

MFAP5

Tbio

Novelty:  0.01839035

p_int:  0.97880151

p_ni:  0.020964751

p_wrong:  0.000233738

Score:  0.327

Data Source:  BioPlex,STRINGDB

TMEM87A

Tdark

Novelty:  0.33614983

p_int:  0.895156784

p_ni:  0.069018886

p_wrong:  0.03582433

Data Source:  BioPlex

CTLA4

Tclin

Novelty:  0.00012781

p_int:  0.887446159

p_ni:  0.083276706

p_wrong:  0.029277135

Score:  0.205

Data Source:  BioPlex,STRINGDB

PATE1

Tbio

Novelty:  0.0705075

p_int:  0.883338566

p_ni:  0.088497617

p_wrong:  0.028163818

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (42)

Reactome (19)

KEGG (5)

PathwayCommons (12)

WikiPathways (6)

Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated NOTCH1 Transmits Signal to the Nucleus	31 targets	R-HSA-2122948
Reactome	Constitutive Signaling by NOTCH1 HD Domain Mutants	15 targets	R-HSA-2691232
Reactome	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58 targets	R-HSA-2894862
Reactome	Constitutive Signaling by NOTCH1 PEST Domain Mutants	58 targets	R-HSA-2644606
Reactome	Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	7 targets	R-HSA-2660826

Name	Explore in Pharos	Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus	31 targets	R-HSA-2122948
Constitutive Signaling by NOTCH1 HD Domain Mutants	15 targets	R-HSA-2691232
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	58 targets	R-HSA-2894862
Constitutive Signaling by NOTCH1 PEST Domain Mutants	58 targets	R-HSA-2644606
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	7 targets	R-HSA-2660826

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (3)

Components (2)

Processes (16)

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1 – 3 of 3

GO Term	Evidence	Assigned by
growth factor activity	Inferred from Direct Assay (IDA)	UniProtKB
Notch binding	Inferred from Physical Interaction (IPI)	UniProtKB
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (12)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3	3	3		85.6
reticulocyte count	EFO_0007986	2	2	2		82.8
neutrophil count	EFO_0004833	2	2	2		71.1
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		64.9
platelet count	EFO_0004309	2	2	2		57.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3		85.6
reticulocyte count	EFO_0007986	2		82.8
neutrophil count	EFO_0004833	2		71.1
mean corpuscular hemoglobin concentration	EFO_0004528	1		64.9
platelet count	EFO_0004309	2		57.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calcium
Complete proteome
Developmental protein
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Notch signaling pathway

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
blood protein measurement
hemoglobin measurement
leukocyte count
mean corpuscular hemoglobin concentration
mean platelet volume
myeloid white cell count
neutrophil count
platelet count
reticulocyte count

MGI Phenotype Find Similar Targets

No Header	No Header
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	jagged 2	VGNC:3389	453210
Macaque	jagged 2		708991
Mouse	jagged 2	MGI:1098270	16450
Rat	jagged 2	RGD:2938	29147
Dog	jagged 2	VGNC:42173	490882

Species	Name	OMA	EggNOG	Inparanoid
Chimp	jagged 2
Macaque	jagged 2
Mouse	jagged 2
Rat	jagged 2
Dog	jagged 2

Publication Statistics

PubMed Score 494.63

PubMed score by year

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PubTator Score 199.53

PubTator score by year

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Related Publications

Text Mined References (56)

GeneRif Annotations (29)

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PMID	Year	Title