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Tbio
JAG2
Protein jagged-2

Protein Summary
Description
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331782
  • ENSP00000328169
  • ENSG00000184916
  • ENST00000347004
  • ENSP00000328566

Symbol
  • HJ2
  • SER2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.87
kinase perturbation
0.84
PubMedID
0.75
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.63   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 444   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.63   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 444   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
VASN
Tbio
Novelty:  0.05424159
p_int:  0.99998421
p_ni:  0.000015567
p_wrong:  2.23e-7
Score:  0.164
Data Source:  BioPlex,STRINGDB
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.999610293
p_ni:  0.000389707
Data Source:  BioPlex
PLPPR1
Tdark
Family:  Enzyme
Novelty:  0.38109551
p_int:  0.998086974
p_ni:  0.00191302
p_wrong:  6e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.997757763
p_ni:  0.002242216
p_wrong:  2.1e-8
Data Source:  BioPlex
STS
Tchem
Family:  Enzyme
Novelty:  0.00324549
p_int:  0.997541032
p_ni:  0.00245894
p_wrong:  2.7e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
ADAM32
Tdark
Family:  Enzyme
Novelty:  0.36071191
p_int:  0.982252907
p_ni:  0.017206138
p_wrong:  0.000540956
Score:  0.216
Data Source:  BioPlex,STRINGDB
MFAP5
Tbio
Novelty:  0.01839035
p_int:  0.97880151
p_ni:  0.020964751
p_wrong:  0.000233738
Score:  0.327
Data Source:  BioPlex,STRINGDB
TMEM87A
Tdark
Novelty:  0.33614983
p_int:  0.895156784
p_ni:  0.069018886
p_wrong:  0.03582433
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.887446159
p_ni:  0.083276706
p_wrong:  0.029277135
Score:  0.205
Data Source:  BioPlex,STRINGDB
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.883338566
p_ni:  0.088497617
p_wrong:  0.028163818
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (42)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
3
3
85.6
reticulocyte count
2
2
2
82.8
neutrophil count
2
2
2
71.1
mean corpuscular hemoglobin concentration
1
1
1
64.9
platelet count
2
2
2
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
85.6
reticulocyte count
2
82.8
neutrophil count
2
71.1
mean corpuscular hemoglobin concentration
1
64.9
platelet count
2
57.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
jagged 2
VGNC:3389
453210
Macaque
jagged 2
708991
Mouse
MGI:1098270
16450
Rat
RGD:2938
29147
Dog
jagged 2
VGNC:42173
490882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
jagged 2
Macaque
jagged 2
Mouse
Rat
Dog
jagged 2
Publication Statistics
PubMed Score 494.63
PubMed score by year
PubTator Score 199.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title