Protein Summary
Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity). The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000331782
- ENSP00000328169
- ENSG00000184916
- ENST00000347004
- ENSP00000328566
- HJ2
- SER2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
disease perturbation | 0.87 | ||
kinase perturbation | 0.84 | ||
PubMedID | 0.75 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 494.63 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 444 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 494.63 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 444 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (138)
VASN
Novelty: 0.05424159
p_int: 0.99998421
p_ni: 0.000015567
p_wrong: 2.23e-7
Score: 0.164
Data Source: BioPlex,STRINGDB
PLPPR1
Family: Enzyme
Novelty: 0.38109551
p_int: 0.998086974
p_ni: 0.00191302
p_wrong: 6e-9
Score: 0.214
Data Source: BioPlex,STRINGDB
TCTN2
Novelty: 0.11617528
p_int: 0.997757763
p_ni: 0.002242216
p_wrong: 2.1e-8
Data Source: BioPlex
STS
Family: Enzyme
Novelty: 0.00324549
p_int: 0.997541032
p_ni: 0.00245894
p_wrong: 2.7e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
ADAM32
Family: Enzyme
Novelty: 0.36071191
p_int: 0.982252907
p_ni: 0.017206138
p_wrong: 0.000540956
Score: 0.216
Data Source: BioPlex,STRINGDB
MFAP5
Novelty: 0.01839035
p_int: 0.97880151
p_ni: 0.020964751
p_wrong: 0.000233738
Score: 0.327
Data Source: BioPlex,STRINGDB
TMEM87A
Novelty: 0.33614983
p_int: 0.895156784
p_ni: 0.069018886
p_wrong: 0.03582433
Data Source: BioPlex
CTLA4
Novelty: 0.00012781
p_int: 0.887446159
p_ni: 0.083276706
p_wrong: 0.029277135
Score: 0.205
Data Source: BioPlex,STRINGDB
PATE1
Novelty: 0.0705075
p_int: 0.883338566
p_ni: 0.088497617
p_wrong: 0.028163818
Data Source: BioPlex
Nearest Tclin Targets
Pathways (42)
Reactome (19)
KEGG (5)
PathwayCommons (12)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Reactome | Constitutive Signaling by NOTCH1 HD Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Constitutive Signaling by NOTCH1 HD Domain Mutants | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (3)
Components (2)
Processes (16)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 3 | 3 | 85.6 | |||||
reticulocyte count | 2 | 2 | 2 | 82.8 | |||||
neutrophil count | 2 | 2 | 2 | 71.1 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 64.9 | |||||
platelet count | 2 | 2 | 2 | 57.6 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 85.6 | |||||
reticulocyte count | 2 | 82.8 | |||||
neutrophil count | 2 | 71.1 | |||||
mean corpuscular hemoglobin concentration | 1 | 64.9 | |||||
platelet count | 2 | 57.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | jagged 2 | VGNC:3389 | 453210 | |||||
Macaque | jagged 2 | 708991 | ||||||
Mouse | MGI:1098270 | 16450 | ||||||
Rat | RGD:2938 | 29147 | ||||||
Dog | jagged 2 | VGNC:42173 | 490882 | |||||
Publication Statistics
PubMed Score 494.63
PubMed score by year
PubTator Score 199.53
PubTator score by year
Related Publications
Text Mined References (56)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
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