Protein Summary
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
- ENST00000254958
- ENSP00000254958
- ENSG00000101384
- JAGL1
- AGS
- AHD
- AWS
- HJ1
- AGS1
- DCHE
- CD339
- JAGL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
PubMedID | 1 | ||
biological process | 0.97 | ||
gene perturbation | 0.95 | ||
transcription factor perturbation | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1041.74 (req: < 5)
Gene RIFs: 217 (req: <= 3)
Antibodies: 656 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1041.74 (req: >= 5)
Gene RIFs: 217 (req: > 3)
Antibodies: 656 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 46
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (235)
Nearest Tclin Targets
Pathways (57)
Reactome (26)
KEGG (8)
PathwayCommons (13)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Reactome | Constitutive Signaling by NOTCH1 HD Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Reactome | Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Constitutive Signaling by NOTCH1 HD Domain Mutants | ||||
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 PEST Domain Mutants | ||||
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | ||||
Viral Interactions (0)
Gene Ontology Terms (52)
Functions (5)
Components (6)
Processes (41)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 10 | 15 | 99.2 | |||||
reticulocyte count | 6 | 5 | 9 | 91.9 | |||||
reticulocyte measurement | 3 | 5 | 7 | 89.8 | |||||
bone density | 3 | 3 | 4 | 87.3 | |||||
hematocrit | 2 | 2 | 2 | 73.4 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 15 | 99.2 | |||||
reticulocyte count | 9 | 91.9 | |||||
reticulocyte measurement | 7 | 89.8 | |||||
bone density | 4 | 87.3 | |||||
hematocrit | 2 | 73.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | jagged 1 | VGNC:6177 | 748073 | |||||
Macaque | jagged 1 | 718580 | ||||||
Mouse | MGI:1095416 | 16449 | ||||||
Rat | RGD:2937 | 29146 | ||||||
Dog | jagged 1 | VGNC:42172 | 485769 | |||||
Publication Statistics
PubMed Score 1041.74
PubMed score by year
PubTator Score 659.74
PubTator score by year
Related Publications
Text Mined References (264)
GeneRif Annotations (217)
Items per page:
0 of 0
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