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Tbio
JADE2
E3 ubiquitin-protein ligase Jade-2

Protein Summary
Description
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo (PubMed:16387653). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A (PubMed:25018020). Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395003
  • ENSP00000378451
  • ENSG00000043143

Symbol
  • KIAA0239
  • PHF15
  • PHF15
  • JADE-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
transcription factor
0.87
protein domain
0.85
cell type or tissue
0.82
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.61   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.61   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
MEAF6
Tbio
Novelty:  0.0914094
p_int:  1
Score:  0.989
Data Source:  BioPlex,STRINGDB
KAT7
Tbio
Family:  TF; Epigenetic
Novelty:  0.01783137
p_int:  0.999999998
p_ni:  1e-9
p_wrong:  1e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
ING5
Tbio
Family:  Epigenetic
Novelty:  0.03585867
p_int:  0.999999994
p_ni:  1e-9
p_wrong:  5e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
ING4
Tbio
Family:  Epigenetic
Novelty:  0.01372992
p_int:  0.999999992
p_ni:  4e-9
p_wrong:  5e-9
Score:  0.995
Data Source:  BioPlex,STRINGDB
ING3
Tbio
Family:  Epigenetic
Novelty:  0.01696145
p_int:  0.999999523
p_ni:  4.77e-7
Score:  0.625
Data Source:  BioPlex,STRINGDB
PIK3C3
Tchem
Family:  Kinase
Novelty:  0.00269825
p_int:  0.99997379
p_ni:  0.00002621
Score:  0.236
Data Source:  BioPlex,STRINGDB
CCDC88A
Tbio
Novelty:  0.01077253
p_int:  0.999799783
p_ni:  0.000200217
Data Source:  BioPlex
TEDC1
Tdark
Novelty:  0.74182963
p_int:  0.999644994
p_ni:  0.000355006
Score:  0.186
Data Source:  BioPlex,STRINGDB
CCDC93
Tdark
Novelty:  0.19116791
p_int:  0.998792406
p_ni:  0.001207594
Score:  0.194
Data Source:  BioPlex,STRINGDB
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.993188906
p_ni:  0.006811092
p_wrong:  3e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
89.3
mean platelet volume
3
2
3
86.7
age at menarche
3
3
2
3
85.9
BMI-adjusted hip circumference
2
4
4
81.4
birth weight
3
3
3
81.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
89.3
mean platelet volume
3
86.7
age at menarche
2
3
85.9
BMI-adjusted hip circumference
4
81.4
birth weight
3
81.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
jade family PHD finger 2
VGNC:4055
462067
Macaque
jade family PHD finger 2
713338
Mouse
MGI:1924151
76901
Rat
RGD:1309152
303113
Dog
jade family PHD finger 2
VGNC:42170
481508
Species
Name
OMA
EggNOG
Inparanoid
Chimp
jade family PHD finger 2
Macaque
jade family PHD finger 2
Mouse
Rat
Dog
jade family PHD finger 2
Publication Statistics
PubMed Score 5.61
PubMed score by year
PubTator Score 2.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title