You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
IZUMO4
Izumo sperm-egg fusion protein 4

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395301
  • ENSP00000378712
  • ENSG00000099840
  • ENST00000395307
  • ENSP00000378718

Symbol
  • C19orf36
  • C19orf36
  • IMAGE:4215339
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
transcription factor
0.67
cell type or tissue
0.53
tissue sample
0.53
cell line
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.93   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.93   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
CD9
Tbio
Novelty:  0.00095308
Score:  0.942
Data Source:  STRINGDB
IZUMO2
Tdark
Novelty:  0.04397237
Score:  0.895
Data Source:  STRINGDB
IZUMO3
Tdark
Novelty:  0.90063897
Score:  0.861
Data Source:  STRINGDB
TMEM242
Tdark
Novelty:  0.99055845
Score:  0.788
Data Source:  STRINGDB
AAAS
Tbio
Novelty:  0.00830233
Score:  0.742
Data Source:  STRINGDB
NUP210
Tbio
Novelty:  0.00784579
Score:  0.742
Data Source:  STRINGDB
NUP85
Tbio
Novelty:  0.02350514
Score:  0.742
Data Source:  STRINGDB
IZUMO1
Tbio
Novelty:  0.01839953
Score:  0.707
Data Source:  STRINGDB
URB1
Tbio
Novelty:  0.04246076
Score:  0.693
Data Source:  STRINGDB
TSSK6
Tbio
Family:  Kinase
Novelty:  0.01684267
Score:  0.635
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (R-HSA-1300645)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Reactome
Fertilization
Reactome
Reproduction
Name
Explore in Pharos
Explore in Source
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Fertilization
Reproduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
6
6
6
98
hemoglobin measurement
5
5
5
97.7
BMI-adjusted hip circumference
3
11
13
96.2
body height
4
4
4
93.1
red blood cell density measurement
2
2
2
92.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
6
98
hemoglobin measurement
5
97.7
BMI-adjusted hip circumference
13
96.2
body height
4
93.1
red blood cell density measurement
2
92.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IZUMO family member 4
VGNC:2336
455564
Macaque
IZUMO family member 4
709954
Mouse
MGI:1918814
71564
Rat
RGD:1564722
362832
Dog
IZUMO family member 4
VGNC:42168
612202
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IZUMO family member 4
Macaque
IZUMO family member 4
Mouse
Rat
Dog
IZUMO family member 4
Publication Statistics
PubMed Score 0.93
PubMed score by year
PubTator Score 1.67
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title