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Tbio
IZUMO1R
Sperm-egg fusion protein Juno

Protein Summary
Description
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328458
  • ENSP00000332963
  • ENSG00000183560
  • ENST00000440961
  • ENSP00000416935

Symbol
  • FOLR4
  • JUNO
  • JUNO
  • FOLR4
  • Folbp3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.62
molecular function
0.6
cell type or tissue
0.49
metabolite
0.45
tissue
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
IZUMO1
Tbio
Novelty:  0.01839953
Score:  0.977
Data Source:  STRINGDB
LY6K
Tbio
Novelty:  0.01861325
Score:  0.936
Data Source:  STRINGDB
CPM
Tchem
Family:  Enzyme
Novelty:  0.00520702
Score:  0.918
Data Source:  STRINGDB
MSLN
Tbio
Novelty:  0.00191245
Score:  0.916
Data Source:  STRINGDB
CD52
Tclin
Novelty:  0.00142013
Score:  0.91
Data Source:  STRINGDB
PRND
Tbio
Novelty:  0.00645201
Score:  0.906
Data Source:  STRINGDB
CD109
Tbio
Novelty:  0.01280272
Score:  0.903
Data Source:  STRINGDB
NRN1
Tbio
Novelty:  0.01198116
Score:  0.902
Data Source:  STRINGDB
FOLR2
Tchem
Novelty:  0.00751372
Score:  0.902
Data Source:  STRINGDB
NRN1L
Tdark
Novelty:  0.56477474
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (106)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
1
4
84.4
1
1
1
8.7
sleep apnea measurement
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
84.4
1
8.7
sleep apnea measurement
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IZUMO1 receptor, JUNO
VGNC:10278
737722
Mouse
MGI:1929185
64931
Rat
RGD:1585174
690037
Pig
IZUMO1 receptor, JUNO
102161281
Opossum
IZUMO1 receptor, JUNO
100014150
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IZUMO1 receptor, JUNO
Mouse
Rat
Pig
IZUMO1 receptor, JUNO
Opossum
IZUMO1 receptor, JUNO
Publication Statistics
PubMed Score 42.72
PubMed score by year
PubTator Score 14.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title