Tbio IYD Iodotyrosine deiodinase 1

Protein Summary

Description

Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT) (PubMed:15289438, PubMed:25395621, PubMed:18434651). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways (PubMed:18434651). Acts more efficiently on monoiodotyrosine than on diiodotyrosine (PubMed:15289438). This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q6PHW0
• C9JFW2
• Q2VPW0
• Q2VPW1
• Q5F1L5
• Q5F1L6
• Q5THM4
• Q6ZP69
• Q7Z7D7
• Q7Z7D8
• IYD-1

Gene Name

• IYD

Ensembl ID

• ENST00000229447
• ENSP00000229447
• ENSG00000009765
• ENST00000344419
• ENSP00000343763
• ENST00000367335
• ENSP00000356304
• ENST00000392256
• ENSP00000376085

Symbol

• C6orf71
• DEHAL1
• TDH4
• IYD-1
• DEHAL1
• C6orf71

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
virus perturbation	0.64
cell type or tissue	0.61
chemical	0.49
tissue sample	0.46

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Peroxidase / Iodotyrosine Deiodinase 1

DTO Classes

Protein / Enzyme / Oxidoreductase / Peroxidase / Iodotyrosine Deiodinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0