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Tbio
IWS1
Protein IWS1 homolog

Protein Summary
Description
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295321
  • ENSP00000295321
  • ENSG00000163166

Symbol
  • IWS1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
kinase perturbation
0.88
histone modification site profile
0.84
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.03   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.03   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  1
Score:  0.525
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.984151516
p_ni:  0.000001137
p_wrong:  0.015847347
Score:  0.205
Data Source:  BioPlex,STRINGDB
SUPT6H
Tbio
Novelty:  0.01099565
Score:  0.999
Data Source:  STRINGDB
CTR9
Tbio
Family:  Enzyme
Novelty:  0.04434964
Score:  0.996
Data Source:  STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
Score:  0.995
Data Source:  STRINGDB
SUPT5H
Tbio
Novelty:  0.00775042
Score:  0.989
Data Source:  STRINGDB
SUPT4H1
Tbio
Novelty:  0.0127914
Score:  0.986
Data Source:  STRINGDB
TCEA1
Tbio
Novelty:  0.00547888
Score:  0.984
Data Source:  STRINGDB
POLR2B
Tbio
Family:  Enzyme
Novelty:  0.0012624
Score:  0.977
Data Source:  STRINGDB
RTF1
Tbio
Family:  Enzyme
Novelty:  0.02255644
Score:  0.973
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Formation of RNA Pol II elongation complex (R-HSA-112382)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Pre-transcription Events
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Elongation
Name
Explore in Pharos
Explore in Source
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
RNA Polymerase II Pre-transcription Events
RNA Polymerase II Transcription
RNA Polymerase II Transcription Elongation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein C measurement
3
4
4
98.8
blood protein measurement
2
1
2
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein C measurement
4
98.8
blood protein measurement
2
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
IWS1, SUPT6H interacting protein
VGNC:6366
738706
Macaque
IWS1, SUPT6H interacting protein
699205
Mouse
MGI:1920723
73473
Rat
RGD:1304762
291705
Dog
IWS1, SUPT6H interacting protein
VGNC:42163
476103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
IWS1, SUPT6H interacting protein
Macaque
IWS1, SUPT6H interacting protein
Mouse
Rat
Dog
IWS1, SUPT6H interacting protein
Publication Statistics
PubMed Score 17.03
PubMed score by year
PubTator Score 6.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title