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Tbio
IVNS1ABP
Influenza virus NS1A-binding protein

Protein Summary
Description
Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (By similarity). Protects cells from cell death induced by actin destabilization (By similarity). Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (PubMed:16582008). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (PubMed:25619834). Inhibits pre-mRNA splicing (in vitro) (PubMed:9696811). (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367498
  • ENSP00000356468
  • ENSG00000116679

Symbol
  • ARA3
  • FLARA3
  • KIAA0850
  • KLHL39
  • NS1
  • NS1BP
  • ND1
  • ARA3
  • NS-1
  • NS1BP
  • FLARA3
  • KLHL39
  • NS1-BP
  • HSPC068
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
transcription factor binding site profile
0.98
protein domain
0.97
drug perturbation
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.52   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.52   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
PRPSAP1
Tbio
Family:  Enzyme
Novelty:  0.08377292
p_int:  0.999999728
p_ni:  2.72e-7
p_wrong:  1e-9
Score:  0.907
Data Source:  BioPlex,STRINGDB
PRPSAP2
Tbio
Family:  Enzyme
Novelty:  0.12017454
p_int:  0.999999539
p_ni:  4.6e-7
p_wrong:  1e-9
Score:  0.85
Data Source:  BioPlex,STRINGDB
KLF5
Tchem
Family:  TF
Novelty:  0.00384971
p_int:  0.991866366
p_ni:  0.004330862
p_wrong:  0.003802772
Data Source:  BioPlex
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.967584978
p_ni:  0.026866136
p_wrong:  0.005548886
Data Source:  BioPlex
NOCT
Tbio
Novelty:  0.01696096
p_int:  0.86558576
p_ni:  0.126219476
p_wrong:  0.008194764
Score:  0.188
Data Source:  BioPlex,STRINGDB
TLX2
Tbio
Family:  TF
Novelty:  0.01105809
Score:  0.8
Data Source:  STRINGDB
ERBB4
Tclin
Family:  Kinase
Novelty:  0.00112919
Score:  0.742
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.742
Data Source:  STRINGDB
OGFRL1
Tchem
Novelty:  0.35118511
Score:  0.72
Data Source:  STRINGDB
TRMT1L
Tdark
Novelty:  0.30029348
Score:  0.718
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
10.9
platelet count
1
1
1
10
reticulocyte count
1
1
1
3.4
reticulocyte measurement
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
10.9
platelet count
1
10
reticulocyte count
1
3.4
reticulocyte measurement
1
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
influenza virus NS1A binding protein
VGNC:1282
457584
Macaque
influenza virus NS1A binding protein
714152
Mouse
MGI:2152389
117198
Dog
influenza virus NS1A binding protein
480043
Horse
influenza virus NS1A binding protein [Source:HGNC Symbol;Acc:HGNC:16951]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
influenza virus NS1A binding protein
Macaque
influenza virus NS1A binding protein
Mouse
Dog
influenza virus NS1A binding protein
Horse
influenza virus NS1A binding protein [Source:HGNC Symbol;Acc:HGNC:16951]
Publication Statistics
PubMed Score 30.52
PubMed score by year
PubTator Score 1450.37
PubTator score by year
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Related Publications
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PMID
Year
Title