Protein Summary
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
- ENST00000368764
- ENSP00000357753
- ENSG00000163207
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.93 | ||
cell type or tissue | 0.76 | ||
cellular component | 0.62 | ||
chemical | 0.6 | ||
gene perturbation | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 635.74 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 701 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 635.74 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 701 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (136)
PDE4DIP
Novelty: 0.03414104
p_int: 0.999828769
p_ni: 0.000171227
p_wrong: 4e-9
Data Source: BioPlex
DDX19B
Family: Enzyme
Novelty: 0.0504568
p_int: 0.999373289
p_ni: 0.000626711
Data Source: BioPlex
RBM24
Novelty: 0.04562076
p_int: 0.999196487
p_ni: 0.000803506
p_wrong: 7e-9
Data Source: BioPlex
Nearest Tclin Targets
Pathways (194)
Reactome (3)
PathwayCommons (1)
WikiPathways (190)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (6)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.2 | 60.4 | |||||
vitamin D measurement | 1 | 1 | 1 | 13.7 | |||||
vitamin D deficiency | 1 | 1 | 1 | 8.9 | |||||
1 | 1 | 0 | 1.1 | 3.6 | |||||
granulocyte count | 1 | 1 | 1 | 3.5 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.2 | 60.4 | |||||
vitamin D measurement | 1 | 13.7 | |||||
vitamin D deficiency | 1 | 8.9 | |||||
0 | 1.1 | 3.6 | |||||
granulocyte count | 1 | 3.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | involucrin | VGNC:53230 | 736637 | |||||
Mouse | MGI:96626 | 16447 | ||||||
Rat | RGD:620141 | 60583 | ||||||
Cow | involucrin | 280830 | ||||||
Pig | involucrin | 407242 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | involucrin | |||||
Mouse | ||||||
Rat | ||||||
Cow | involucrin | |||||
Pig | involucrin | |||||
Publication Statistics
PubMed Score 635.74
PubMed score by year
PubTator Score 211.30
PubTator score by year
Related Publications
Text Mined References (59)
GeneRif Annotations (35)
Items per page:
0 of 0
PMID | Year | Title |
|---|