Tbio IVL Involucrin

Protein Summary

Description

Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07476
• Q5T7P4

Gene Name

• IVL

Ensembl ID

• ENST00000368764
• ENSP00000357753
• ENSG00000163207

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.93
cell type or tissue	0.76
cellular component	0.62
chemical	0.6
gene perturbation	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 667.82   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 701   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 667.82   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 701   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0