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Tbio
ITSN2
Intersectin-2

Protein Summary
Description
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355123
  • ENSP00000347244
  • ENSG00000198399
  • ENST00000361999
  • ENSP00000354561
  • ENST00000406921
  • ENSP00000384499

Symbol
  • KIAA1256
  • SH3D1B
  • SWAP
  • SWA
  • SWAP
  • SH3D1B
  • SH3P18
  • PRO2015
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.94
disease perturbation
0.87
transcription factor
0.84
interacting protein
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.74   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (213)
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.999999999
p_ni:  1e-9
Score:  0.978
Data Source:  BioPlex,STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999995
p_ni:  2e-9
p_wrong:  3e-9
Score:  0.957
Data Source:  BioPlex,STRINGDB
NCKIPSD
Tbio
Novelty:  0.07453111
p_int:  0.999999846
p_ni:  1.53e-7
p_wrong:  1e-9
Score:  0.257
Data Source:  BioPlex,STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.976308893
p_ni:  0.000201689
p_wrong:  0.023489419
Score:  0.975
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.986
Data Source:  STRINGDB
FNBP1
Tbio
Novelty:  0.03879767
Score:  0.984
Data Source:  STRINGDB
FNBP1L
Tbio
Novelty:  0.01235857
Score:  0.983
Data Source:  STRINGDB
TRIP10
Tbio
Novelty:  0.01553463
Score:  0.982
Data Source:  STRINGDB
AP2B1
Tbio
Novelty:  0.00921093
Score:  0.982
Data Source:  STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
Score:  0.978
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
5
90.4
neutrophil count
3
2
3
77
leukocyte count
1
1
1
49.5
feeling "fed-up" measurement
1
2
0
5.8
47.5
low density lipoprotein cholesterol measurement
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
90.4
neutrophil count
3
77
leukocyte count
1
49.5
feeling "fed-up" measurement
0
5.8
47.5
low density lipoprotein cholesterol measurement
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
intersectin 2
VGNC:279
459066
Mouse
MGI:1338049
20403
Rat
RGD:1590890
313934
Dog
intersectin 2
VGNC:42162
475683
Horse
intersectin 2
VGNC:19200
100056119
Species
Name
OMA
EggNOG
Inparanoid
Chimp
intersectin 2
Mouse
Rat
Dog
intersectin 2
Horse
intersectin 2
Publication Statistics
PubMed Score 29.74
PubMed score by year
PubTator Score 36.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title