Protein Summary
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed:23999003). This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
- ENST00000355123
- ENSP00000347244
- ENSG00000198399
- ENST00000361999
- ENSP00000354561
- ENST00000406921
- ENSP00000384499
- KIAA1256
- SH3D1B
- SWAP
- SWA
- SWAP
- SH3D1B
- SH3P18
- PRO2015
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
transcription factor perturbation | 0.94 | ||
disease perturbation | 0.87 | ||
transcription factor | 0.84 | ||
interacting protein | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.74 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 71 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.74 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 71 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (213)
EPS15L1
Novelty: 0.06929299
p_int: 0.999999999
p_ni: 1e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
AP2M1
Novelty: 0.00769368
p_int: 0.999999995
p_ni: 2e-9
p_wrong: 3e-9
Score: 0.957
Data Source: BioPlex,STRINGDB
NCKIPSD
Novelty: 0.07453111
p_int: 0.999999846
p_ni: 1.53e-7
p_wrong: 1e-9
Score: 0.257
Data Source: BioPlex,STRINGDB
AP2S1
Novelty: 0.01931502
p_int: 0.976308893
p_ni: 0.000201689
p_wrong: 0.023489419
Score: 0.975
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (4)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 3 | 3 | 5 | 90.4 | |||||
neutrophil count | 3 | 2 | 3 | 77 | |||||
leukocyte count | 1 | 1 | 1 | 49.5 | |||||
feeling "fed-up" measurement | 1 | 2 | 0 | 5.8 | 47.5 | ||||
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 46.9 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 5 | 90.4 | |||||
neutrophil count | 3 | 77 | |||||
leukocyte count | 1 | 49.5 | |||||
feeling "fed-up" measurement | 0 | 5.8 | 47.5 | ||||
low density lipoprotein cholesterol measurement | 1 | 46.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | intersectin 2 | VGNC:279 | 459066 | |||||
Mouse | MGI:1338049 | 20403 | ||||||
Rat | RGD:1590890 | 313934 | ||||||
Dog | intersectin 2 | VGNC:42162 | 475683 | |||||
Horse | intersectin 2 | VGNC:19200 | 100056119 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | intersectin 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | intersectin 2 | |||||
Horse | intersectin 2 | |||||
Publication Statistics
PubMed Score 29.74
PubMed score by year
PubTator Score 36.07
PubTator score by year
Related Publications
Text Mined References (33)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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