Tbio ITSN1 Intersectin-1

Protein Summary

Description

Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1. The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15811
• A7Y322
• A8CTX8
• A8CTY3
• A8CTY7
• A8D7D0
• A8DCP3
• B4DTM2
• E7ERJ1
• E9PE44
• E9PG01
• E9PHV2
• O95216
• Q0PW94
• Q0PW95
• Q0PW97
• Q14BD3
• Q1ED40
• Q20BK3
• Q9UET5
• Q9UK60
• Q9UNK1
• Q9UNK2
• Q9UQ92

Gene Name

• ITSN1

Ensembl ID

• ENST00000381291
• ENSP00000370691
• ENSG00000205726
• ENST00000381318
• ENSP00000370719
• ENST00000399338
• ENSP00000382275
• ENST00000399349
• ENSP00000382286
• ENST00000399352
• ENSP00000382289
• ENST00000399353
• ENSP00000382290
• ENST00000399367
• ENSP00000382301

Symbol

• ITSN
• SH3D1A
• ITSN
• SH3D1A
• SH3P17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
disease perturbation	0.99
virus perturbation	0.97
transcription factor perturbation	0.91
transcription factor	0.87

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Intersectin-1

Protein / Enzyme Modulator / G-protein Modulator / Intersectin-1

Protein / Calcium-binding Protein / Intersectin-1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Intersectin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.67   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.67   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0