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Tdark
ITPRIP
Inositol 1,4,5-trisphosphate receptor-interacting protein

Protein Summary
Description
Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release. This gene encodes a membrane-associated protein that binds the inositol 1,4,5-trisphosphate receptor (ITPR). The encoded protein enhances the sensitivity of ITPR to intracellular calcium signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278071
  • ENSP00000278071
  • ENSG00000148841
  • ENST00000337478
  • ENSP00000337178
  • ENST00000358187
  • ENSP00000350915
  • ENST00000647721
  • ENSP00000497746

Symbol
  • DANGER
  • KIAA1754
  • DANGER
  • KIAA1754
  • bA127L20
  • bA127L20.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
tissue sample
0.67
cell type or tissue
0.64
microRNA
0.56
cell line
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.2   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.2   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.99747607
p_ni:  0.00252393
Data Source:  BioPlex
RASSF1
Tbio
Novelty:  0.00137149
p_int:  0.995818444
p_ni:  0.004181556
Score:  0.228
Data Source:  BioPlex,STRINGDB
GALNT8
Tbio
Family:  Enzyme
Novelty:  0.19956817
p_int:  0.989496295
p_ni:  0.010503698
p_wrong:  6e-9
Data Source:  BioPlex
MAS1
Tchem
Family:  GPCR
Novelty:  0.0089712
p_int:  0.976689301
p_ni:  0.023310699
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.955563406
p_ni:  0.044436594
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.951862905
p_ni:  0.048137092
p_wrong:  3e-9
Data Source:  BioPlex
NRROS
Tbio
Novelty:  0.08976002
p_int:  0.932414697
p_ni:  0.067585303
Score:  0.153
Data Source:  BioPlex,STRINGDB
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.89385583
p_ni:  0.10614417
Data Source:  BioPlex
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.883524062
p_ni:  0.116475938
Data Source:  BioPlex
CD1B
Tbio
Novelty:  0.00102701
p_int:  0.876888061
p_ni:  0.123111939
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
65.7
smoking status measurement
2
1
2
33.1
mathematical ability
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
65.7
smoking status measurement
2
33.1
mathematical ability
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
inositol 1,4,5-trisphosphate receptor interacting protein
716246
Mouse
MGI:1289258
100048534
Dog
inositol 1,4,5-trisphosphate receptor interacting protein
VGNC:52996
609723
Horse
inositol 1,4,5-trisphosphate receptor interacting protein
VGNC:19197
100069597
Cow
inositol 1,4,5-trisphosphate receptor interacting protein
VGNC:30349
538685
Species
Name
OMA
EggNOG
Inparanoid
Macaque
inositol 1,4,5-trisphosphate receptor interacting protein
Mouse
Dog
inositol 1,4,5-trisphosphate receptor interacting protein
Horse
inositol 1,4,5-trisphosphate receptor interacting protein
Cow
inositol 1,4,5-trisphosphate receptor interacting protein
Publication Statistics
PubMed Score 4.20
PubMed score by year
PubTator Score 6.04
PubTator score by year
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Related Publications
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PMID
Year
Title