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Tchem
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1

Protein Summary
Description
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302640
  • ENSP00000306253
  • ENSG00000150995
  • ENST00000357086
  • ENSP00000349597
  • ENST00000443694
  • ENSP00000401671
  • ENST00000456211
  • ENSP00000397885
  • ENST00000648309
  • ENSP00000497026
  • ENST00000649015
  • ENSP00000497605

Symbol
  • INSP3R1
  • ACV
  • CLA4
  • IP3R
  • IP3R1
  • SCA15
  • SCA16
  • SCA29
  • INSP3R1
  • PPP1R94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.99
hub protein
0.98
protein domain
0.97
biological process
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 961.96   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 961.96   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (317)
TESPA1
Tbio
Novelty:  0.12779533
p_int:  0.999999994
p_ni:  6e-9
Score:  0.764
Data Source:  BioPlex,STRINGDB
MRVI1
Tbio
Novelty:  0.02987514
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
RAB29
Tchem
Family:  Enzyme
Novelty:  0.03751616
p_int:  0.9999479
p_ni:  0.0000521
Score:  0.242
Data Source:  BioPlex,STRINGDB
RASEF
Tbio
Novelty:  0.08877022
p_int:  0.996227163
p_ni:  0.003772836
Data Source:  BioPlex
FBXL14
Tbio
Novelty:  0.21211079
p_int:  0.971097466
p_ni:  0.028902534
Score:  0.225
Data Source:  BioPlex,STRINGDB
CA8
Tbio
Family:  Enzyme
Novelty:  0.0041859
p_int:  0.971006779
p_ni:  0.028993221
Score:  0.761
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.968528571
p_ni:  0.031471403
p_wrong:  2.6e-8
Score:  0.727
Data Source:  BioPlex,STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.964171432
p_ni:  0.035828562
p_wrong:  5e-9
Data Source:  BioPlex
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
Score:  0.984
Data Source:  Reactome,STRINGDB
STIM1
Tbio
Novelty:  0.00116516
Score:  0.982
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (118)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 44
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Beta-catenin independent WNT signaling
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) induces NFAT activation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Beta-catenin independent WNT signaling
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) induces NFAT activation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (40)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
3
3
91.1
3
1
0
1.1
54.4
C-reactive protein measurement
1
1
1
53.7
hematocrit
2
1
2
52.7
hemoglobin measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
91.1
0
1.1
54.4
C-reactive protein measurement
1
53.7
hematocrit
2
52.7
hemoglobin measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol 1,4,5-trisphosphate receptor type 1
VGNC:7976
460134
Macaque
inositol 1,4,5-trisphosphate receptor type 1
703669
Mouse
MGI:96623
16438
Rat
RGD:2933
25262
Dog
inositol 1,4,5-trisphosphate receptor type 1
VGNC:42157
476548
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol 1,4,5-trisphosphate receptor type 1
Macaque
inositol 1,4,5-trisphosphate receptor type 1
Mouse
Rat
Dog
inositol 1,4,5-trisphosphate receptor type 1
Publication Statistics
PubMed Score 961.96
PubMed score by year
PubTator Score 222.94
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title