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Tchem
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1

Protein Summary
Description
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302640
  • ENSP00000306253
  • ENSG00000150995
  • ENST00000357086
  • ENSP00000349597
  • ENST00000443694
  • ENSP00000401671
  • ENST00000456211
  • ENSP00000397885
  • ENST00000648309
  • ENSP00000497026
  • ENST00000649015
  • ENSP00000497605

Symbol
  • INSP3R1
  • ACV
  • CLA4
  • IP3R
  • IP3R1
  • SCA15
  • SCA16
  • SCA29
  • INSP3R1
  • PPP1R94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.99
hub protein
0.98
protein domain
0.97
biological process
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1089.98   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1089.98   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0