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Tchem
ITPKC
Inositol-trisphosphate 3-kinase C

Protein Summary
Description
Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263370
  • ENSP00000263370
  • ENSG00000086544

Symbol
  • IP3KC
  • IP3KC
  • IP3-3KC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
molecular function
0.93
transcription factor
0.84
transcription factor binding site profile
0.75
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.63   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.63   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (85)
PIP
Tbio
Novelty:  0.00208509
p_int:  0.999999934
p_ni:  2.7e-8
p_wrong:  3.9e-8
Data Source:  BioPlex
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.999999857
p_ni:  1.41e-7
p_wrong:  2e-9
Score:  0.415
Data Source:  BioPlex,STRINGDB
RARRES1
Tbio
Family:  Enzyme
Novelty:  0.04701793
p_int:  0.999995479
p_ni:  0.000001514
p_wrong:  0.000003007
Data Source:  BioPlex
ERP44
Tbio
Novelty:  0.02352693
p_int:  0.993092068
p_ni:  2.6e-8
p_wrong:  0.006907906
Score:  0.239
Data Source:  BioPlex,STRINGDB
IPMK
Tbio
Family:  Kinase
Novelty:  0.01837813
Score:  0.959
Data Source:  STRINGDB
INPP5A
Tchem
Family:  Enzyme
Novelty:  0.03249263
Score:  0.948
Data Source:  STRINGDB
MINPP1
Tbio
Family:  Enzyme
Novelty:  0.02584444
Score:  0.94
Data Source:  STRINGDB
OCRL
Tbio
Family:  Enzyme
Novelty:  0.00555539
Score:  0.937
Data Source:  STRINGDB
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.934
Data Source:  STRINGDB
INPP5D
Tbio
Family:  Enzyme
Novelty:  0.00630254
Score:  0.932
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (13)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
nicotine metabolite ratio
2
6
6
99.1
cigarettes per day measurement
5
4
5
97.4
melanoma-derived growth regulatory protein measurement
2
4
2
1.2
96.4
hematocrit
5
9
12
91.1
hemoglobin measurement
5
8
12
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
nicotine metabolite ratio
6
99.1
cigarettes per day measurement
5
97.4
melanoma-derived growth regulatory protein measurement
2
1.2
96.4
hematocrit
12
91.1
hemoglobin measurement
12
90.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol-trisphosphate 3-kinase C
VGNC:7685
468885
Macaque
inositol-trisphosphate 3-kinase C
722078
Mouse
MGI:2442554
233011
Rat
RGD:631336
308451
Dog
inositol-trisphosphate 3-kinase C
VGNC:42156
612489
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol-trisphosphate 3-kinase C
Macaque
inositol-trisphosphate 3-kinase C
Mouse
Rat
Dog
inositol-trisphosphate 3-kinase C
Publication Statistics
PubMed Score 41.63
PubMed score by year
PubTator Score 27.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title