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Tchem
ITPKB
Inositol-trisphosphate 3-kinase B

Protein Summary
Description
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272117
  • ENSP00000272117
  • ENSG00000143772
  • ENST00000366784
  • ENSP00000355748
  • ENST00000429204
  • ENSP00000411152

Symbol
  • IP3K
  • IP3KB
  • PIG37
  • IP3K-B
  • IP3-3KB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
molecular function
0.93
PubMedID
0.84
cell type or tissue
0.79
cell line
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.43   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.43   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (522)
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.965
Data Source:  STRINGDB
IPMK
Tbio
Family:  Kinase
Novelty:  0.01837813
Score:  0.963
Data Source:  STRINGDB
INPP5D
Tbio
Family:  Enzyme
Novelty:  0.00630254
Score:  0.945
Data Source:  STRINGDB
INPP5A
Tchem
Family:  Enzyme
Novelty:  0.03249263
Score:  0.944
Data Source:  STRINGDB
ITPK1
Tbio
Family:  Kinase
Novelty:  0.02790263
Score:  0.942
Data Source:  STRINGDB
PLCG1
Tchem
Family:  Enzyme
Novelty:  0.00110273
Score:  0.939
Data Source:  STRINGDB
MINPP1
Tbio
Family:  Enzyme
Novelty:  0.02584444
Score:  0.933
Data Source:  STRINGDB
PLCG2
Tchem
Family:  Enzyme
Novelty:  0.00294726
Score:  0.933
Data Source:  STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
Score:  0.928
Data Source:  STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (12)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of IP3 and IP4 in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of IP3 and IP4 in the cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
63.1
eosinophil count
2
2
2
61.4
eosinophil percentage of leukocytes
1
1
1
57.3
1
1
0
1.1
49.5
1
1
0
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
63.1
eosinophil count
2
61.4
eosinophil percentage of leukocytes
1
57.3
0
1.1
49.5
0
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol-trisphosphate 3-kinase B
VGNC:6892
457789
Macaque
inositol-trisphosphate 3-kinase B
106993259
Mouse
MGI:109235
320404
Rat
RGD:2932
54260
Dog
inositol-trisphosphate 3-kinase B
VGNC:42155
490383
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol-trisphosphate 3-kinase B
Macaque
inositol-trisphosphate 3-kinase B
Mouse
Rat
Dog
inositol-trisphosphate 3-kinase B
Publication Statistics
PubMed Score 45.43
PubMed score by year
PubTator Score 27.05
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title