You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ITPA
Inosine triphosphate pyrophosphatase

Protein Summary
Description
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380113
  • ENSP00000369456
  • ENSG00000125877
  • ENST00000399838
  • ENSP00000382732
  • ENST00000455664
  • ENSP00000413282

Symbol
  • C20orf37
  • My049
  • ITPase
  • NTPase
  • C20orf37
  • dJ794I6.3
  • HLC14-06-P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.96
histone modification site profile
0.68
molecular function
0.67
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.47   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.47   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (313)
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.999999905
p_ni:  9.5e-8
Data Source:  BioPlex
HHIPL1
Tdark
Novelty:  0.57780473
p_int:  0.998908318
p_ni:  0.001091578
p_wrong:  1.04e-7
Data Source:  BioPlex
FAM3B
Tbio
Novelty:  0.00844967
p_int:  0.994094227
p_ni:  0.005905715
p_wrong:  5.9e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
P2RX5
Tchem
Family:  IC
Novelty:  0.01591178
p_int:  0.993821766
p_ni:  0.005404968
p_wrong:  0.000773265
Data Source:  BioPlex
VPS4B
Tchem
Novelty:  0.00788708
p_int:  0.992453479
p_ni:  0.007545936
p_wrong:  5.85e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.990131557
p_ni:  0.006731233
p_wrong:  0.00313721
Data Source:  BioPlex
CCL22
Tbio
Novelty:  0.00245992
p_int:  0.98866779
p_ni:  0.009061978
p_wrong:  0.002270232
Data Source:  BioPlex
PPM1L
Tbio
Family:  Enzyme
Novelty:  0.09146774
p_int:  0.982355557
p_ni:  0.016183399
p_wrong:  0.001461045
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.979913621
p_ni:  0.019622064
p_wrong:  0.000464314
Score:  0.183
Data Source:  BioPlex,STRINGDB
Q8NFQ8
Tbio
Novelty:  0.08912351
p_int:  0.979218567
p_ni:  0.018441927
p_wrong:  0.002339506
Data Source:  BioPlex
Nearest Tclin Targets (23)
Explore Nearest Tclin Targets
1 – 5 of 21
PDE5A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE2A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6H
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Purine catabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
0
14.8
81.4
serum gamma-glutamyl transferase measurement
2
2
2
78.7
household income
2
3
4
55.1
hematocrit
1
1
1
48.5
hemoglobin measurement
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
14.8
81.4
serum gamma-glutamyl transferase measurement
2
78.7
household income
4
55.1
hematocrit
1
48.5
hemoglobin measurement
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inosine triphosphatase
VGNC:6172
746982
Macaque
inosine triphosphatase
717257
Mouse
MGI:96622
16434
Rat
RGD:1589751
311422
Dog
inosine triphosphatase
VGNC:42152
609255
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inosine triphosphatase
Macaque
inosine triphosphatase
Mouse
Rat
Dog
inosine triphosphatase
Publication Statistics
PubMed Score 413.47
PubMed score by year
PubTator Score 246.36
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title