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Tbio
ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

Protein Summary
Description
Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266041
  • ENSP00000266041
  • ENSG00000055955
  • ENST00000406595
  • ENSP00000384425

Symbol
  • IHRP
  • ITIHL1
  • PK120
  • H4P
  • IHRP
  • GP120
  • PK120
  • ITIHL1
  • PK-120
  • ITI-HC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
virus perturbation
1
disease perturbation
0.83
gene perturbation
0.66
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3357.48   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 395   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3357.48   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 395   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
CCR5
Tclin
Family:  GPCR
Novelty:  0.00022549
Score:  0.959
Data Source:  STRINGDB
ERVW-1
Tbio
Novelty:  0.00038992
Score:  0.953
Data Source:  STRINGDB
APOH
Tbio
Novelty:  0.00049117
Score:  0.949
Data Source:  STRINGDB
CD4
Tclin
Novelty:  0.00001217
Score:  0.937
Data Source:  STRINGDB
SERPINA4
Tbio
Novelty:  0.00483207
Score:  0.935
Data Source:  STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
Score:  0.93
Data Source:  STRINGDB
ITIH3
Tbio
Novelty:  0.04201144
Score:  0.92
Data Source:  STRINGDB
SELENOP
Tbio
Novelty:  0.00194637
Score:  0.917
Data Source:  STRINGDB
SPP2
Tbio
Novelty:  0.04515855
Score:  0.917
Data Source:  STRINGDB
ENPEP
Tchem
Family:  Enzyme
Novelty:  0.00112857
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
3
8
8
92.2
waist circumference
2
4
4
90.2
body height
2
2
2
79.8
worry measurement
2
4
3
7.6
79.3
BMI-adjusted waist-hip ratio
5
4
7
78.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
8
92.2
waist circumference
4
90.2
body height
2
79.8
worry measurement
3
7.6
79.3
BMI-adjusted waist-hip ratio
7
78.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inter-alpha-trypsin inhibitor heavy chain family member 4
VGNC:7073
460437
Macaque
inter-alpha-trypsin inhibitor heavy chain family member 4
695305
Mouse
MGI:109536
16427
Rat
RGD:70881
54404
Dog
inter-alpha-trypsin inhibitor heavy chain family member 4
VGNC:42147
607088
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inter-alpha-trypsin inhibitor heavy chain family member 4
Macaque
inter-alpha-trypsin inhibitor heavy chain family member 4
Mouse
Rat
Dog
inter-alpha-trypsin inhibitor heavy chain family member 4
Publication Statistics
PubMed Score 3357.48
PubMed score by year
PubTator Score 2512.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title